Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women

Kiyoyasu Yamada, Satoshi Isobe, Makoto Hirai, Kazumasa Unno, Satoru Ohshima, Yasuo Takada, Hideo Izawa, Kazunari Abe, Mitsuhiro Yokota, Toyoaki Murohara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: In postmenopausal women, it has been reported that the plasma estrogen levels diminish immediately after menopause, and that this phenomenon affects left ventricular (LV) function and volumes. However, the effects of age on LV function and volumes for a relatively short period in the postmenopausal women remain to be established. Electrocardiographically gated-myocardial single-photon emission computed tomography (SPECT) has recently provided accurate estimations of perfusion, cardiac systolic and diastolic functions. We investigated the age-related changes in LV function and volumes in postmenopausal women using electrocardiographically gated-myocardial scintigraphy. Methods: Twenty-two consecutive healthy postmenopausal women (mean age of 63.8 ± 9.4 years, from 42 to 77 years) without cardiac disease underwent stress/rest technetium-99m tetrofosmin gated-myocardial SPECT with 16 frames per cardiac cycle at baseline and follow-up (1.0 ± 0.3 years later). LV ejection fraction (LVEF) and LV volumes were calculated by QGS software. Fourier series were retained for the analysis of the volume curve. From this volume curve, we derived the following diastolic indices: peak filling rate (PFR) and time to PFR (TPFR). Results: End-systolic volume index (ESVI) significantly decreased at postexercise (p = 0.02) and tended to decrease at rest (p = 0.06) from the baseline to the follow-up study. LVEF significantly increased at both postexercise (p = 0.01) and rest (p = 0.03) from the baseline to the follow-up study. The TPFR at rest tended to be prolonged from the baseline to the follow-up study (p = 0.07). The absolute increase in LVEF at postexercise tended to decrease with age [4.8% (50s) vs. 3.4% (60s) vs. 1.2% (70s)]. Conclusions: An age-related change in cardiac performance is apparent at an approximately 1 year follow-up in postmenopausal women. In particular, the increase in LV systolic function tends to show the greatest value in the 50s subjects among the 3 generations.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalAnnals of Nuclear Medicine
Volume20
Issue number10
DOIs
Publication statusPublished - 01-12-2006
Externally publishedYes

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Left Ventricular Function
Single-Photon Emission-Computed Tomography
Postmenopause
Myocardial Perfusion Imaging
Fourier Analysis
Menopause
Stroke Volume
Heart Diseases
Estrogens
Software
Perfusion

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Yamada, K., Isobe, S., Hirai, M., Unno, K., Ohshima, S., Takada, Y., ... Murohara, T. (2006). Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women. Annals of Nuclear Medicine, 20(10), 677-681. https://doi.org/10.1007/BF02984679
Yamada, Kiyoyasu ; Isobe, Satoshi ; Hirai, Makoto ; Unno, Kazumasa ; Ohshima, Satoru ; Takada, Yasuo ; Izawa, Hideo ; Abe, Kazunari ; Yokota, Mitsuhiro ; Murohara, Toyoaki. / Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women. In: Annals of Nuclear Medicine. 2006 ; Vol. 20, No. 10. pp. 677-681.
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abstract = "Objectives: In postmenopausal women, it has been reported that the plasma estrogen levels diminish immediately after menopause, and that this phenomenon affects left ventricular (LV) function and volumes. However, the effects of age on LV function and volumes for a relatively short period in the postmenopausal women remain to be established. Electrocardiographically gated-myocardial single-photon emission computed tomography (SPECT) has recently provided accurate estimations of perfusion, cardiac systolic and diastolic functions. We investigated the age-related changes in LV function and volumes in postmenopausal women using electrocardiographically gated-myocardial scintigraphy. Methods: Twenty-two consecutive healthy postmenopausal women (mean age of 63.8 ± 9.4 years, from 42 to 77 years) without cardiac disease underwent stress/rest technetium-99m tetrofosmin gated-myocardial SPECT with 16 frames per cardiac cycle at baseline and follow-up (1.0 ± 0.3 years later). LV ejection fraction (LVEF) and LV volumes were calculated by QGS software. Fourier series were retained for the analysis of the volume curve. From this volume curve, we derived the following diastolic indices: peak filling rate (PFR) and time to PFR (TPFR). Results: End-systolic volume index (ESVI) significantly decreased at postexercise (p = 0.02) and tended to decrease at rest (p = 0.06) from the baseline to the follow-up study. LVEF significantly increased at both postexercise (p = 0.01) and rest (p = 0.03) from the baseline to the follow-up study. The TPFR at rest tended to be prolonged from the baseline to the follow-up study (p = 0.07). The absolute increase in LVEF at postexercise tended to decrease with age [4.8{\%} (50s) vs. 3.4{\%} (60s) vs. 1.2{\%} (70s)]. Conclusions: An age-related change in cardiac performance is apparent at an approximately 1 year follow-up in postmenopausal women. In particular, the increase in LV systolic function tends to show the greatest value in the 50s subjects among the 3 generations.",
author = "Kiyoyasu Yamada and Satoshi Isobe and Makoto Hirai and Kazumasa Unno and Satoru Ohshima and Yasuo Takada and Hideo Izawa and Kazunari Abe and Mitsuhiro Yokota and Toyoaki Murohara",
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Yamada, K, Isobe, S, Hirai, M, Unno, K, Ohshima, S, Takada, Y, Izawa, H, Abe, K, Yokota, M & Murohara, T 2006, 'Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women', Annals of Nuclear Medicine, vol. 20, no. 10, pp. 677-681. https://doi.org/10.1007/BF02984679

Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women. / Yamada, Kiyoyasu; Isobe, Satoshi; Hirai, Makoto; Unno, Kazumasa; Ohshima, Satoru; Takada, Yasuo; Izawa, Hideo; Abe, Kazunari; Yokota, Mitsuhiro; Murohara, Toyoaki.

In: Annals of Nuclear Medicine, Vol. 20, No. 10, 01.12.2006, p. 677-681.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Changes with age in left ventricular function and volumes at rest and postexercise in postmenopausal women

AU - Yamada, Kiyoyasu

AU - Isobe, Satoshi

AU - Hirai, Makoto

AU - Unno, Kazumasa

AU - Ohshima, Satoru

AU - Takada, Yasuo

AU - Izawa, Hideo

AU - Abe, Kazunari

AU - Yokota, Mitsuhiro

AU - Murohara, Toyoaki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Objectives: In postmenopausal women, it has been reported that the plasma estrogen levels diminish immediately after menopause, and that this phenomenon affects left ventricular (LV) function and volumes. However, the effects of age on LV function and volumes for a relatively short period in the postmenopausal women remain to be established. Electrocardiographically gated-myocardial single-photon emission computed tomography (SPECT) has recently provided accurate estimations of perfusion, cardiac systolic and diastolic functions. We investigated the age-related changes in LV function and volumes in postmenopausal women using electrocardiographically gated-myocardial scintigraphy. Methods: Twenty-two consecutive healthy postmenopausal women (mean age of 63.8 ± 9.4 years, from 42 to 77 years) without cardiac disease underwent stress/rest technetium-99m tetrofosmin gated-myocardial SPECT with 16 frames per cardiac cycle at baseline and follow-up (1.0 ± 0.3 years later). LV ejection fraction (LVEF) and LV volumes were calculated by QGS software. Fourier series were retained for the analysis of the volume curve. From this volume curve, we derived the following diastolic indices: peak filling rate (PFR) and time to PFR (TPFR). Results: End-systolic volume index (ESVI) significantly decreased at postexercise (p = 0.02) and tended to decrease at rest (p = 0.06) from the baseline to the follow-up study. LVEF significantly increased at both postexercise (p = 0.01) and rest (p = 0.03) from the baseline to the follow-up study. The TPFR at rest tended to be prolonged from the baseline to the follow-up study (p = 0.07). The absolute increase in LVEF at postexercise tended to decrease with age [4.8% (50s) vs. 3.4% (60s) vs. 1.2% (70s)]. Conclusions: An age-related change in cardiac performance is apparent at an approximately 1 year follow-up in postmenopausal women. In particular, the increase in LV systolic function tends to show the greatest value in the 50s subjects among the 3 generations.

AB - Objectives: In postmenopausal women, it has been reported that the plasma estrogen levels diminish immediately after menopause, and that this phenomenon affects left ventricular (LV) function and volumes. However, the effects of age on LV function and volumes for a relatively short period in the postmenopausal women remain to be established. Electrocardiographically gated-myocardial single-photon emission computed tomography (SPECT) has recently provided accurate estimations of perfusion, cardiac systolic and diastolic functions. We investigated the age-related changes in LV function and volumes in postmenopausal women using electrocardiographically gated-myocardial scintigraphy. Methods: Twenty-two consecutive healthy postmenopausal women (mean age of 63.8 ± 9.4 years, from 42 to 77 years) without cardiac disease underwent stress/rest technetium-99m tetrofosmin gated-myocardial SPECT with 16 frames per cardiac cycle at baseline and follow-up (1.0 ± 0.3 years later). LV ejection fraction (LVEF) and LV volumes were calculated by QGS software. Fourier series were retained for the analysis of the volume curve. From this volume curve, we derived the following diastolic indices: peak filling rate (PFR) and time to PFR (TPFR). Results: End-systolic volume index (ESVI) significantly decreased at postexercise (p = 0.02) and tended to decrease at rest (p = 0.06) from the baseline to the follow-up study. LVEF significantly increased at both postexercise (p = 0.01) and rest (p = 0.03) from the baseline to the follow-up study. The TPFR at rest tended to be prolonged from the baseline to the follow-up study (p = 0.07). The absolute increase in LVEF at postexercise tended to decrease with age [4.8% (50s) vs. 3.4% (60s) vs. 1.2% (70s)]. Conclusions: An age-related change in cardiac performance is apparent at an approximately 1 year follow-up in postmenopausal women. In particular, the increase in LV systolic function tends to show the greatest value in the 50s subjects among the 3 generations.

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