Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium

Yasuyo Tsukushi, Nobuo Kido, Kazuhiko Saeki, Tsuyoshi Sugiyama, Naoki Koide, Isamu Mori, Tomoaki Yoshida, Takashi Yokochi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The biological actions of lipopolysaccharides (LPSs) from Sinorhizobium meliloti, Mesorhizobium loti and Escherichia coli were compared. In biological activities including lethality, production of tumor necrosis factor (TNF)-α and nitric oxide (NO), adjuvant action and Limulus activity, LPS from S. meliloti exhibited stronger actions than LPS from M. loti, but had a weaker action than LPS from E. coli. On the other hand, M. loti LPS showed a higher activity to activate human complement than S. meliloti LPS. Further, there was a significant difference in polymyxin B binding between S. meliloti LPS and M. loti LPS, suggesting a difference in the lipid A structure. LPSs from S. meliloti and M. loti seem to exhibit characteristic biological actions that may be dependent on the difference in the lipid A structure.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalJournal of Endotoxin Research
Issue number1
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases


Dive into the research topics of 'Characteristic biological activities of lipopolysaccharides from Sinorhizobium and Mesorhizobium'. Together they form a unique fingerprint.

Cite this