Characteristics and causes of immune dysfunction related to uremia and dialysis

Aline Borsato Hauser, Andréa E M Stinghen, Sawako Kato, Sérgio Bucharles, Carlos Aita, Yukio Yuzawa, Roberto Pecoits-Filho

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

From the immunologic viewpoint, chronic kidney disease (CKD) is characterized by disorders of both the innate and adaptive systems, generating a complex and still not fully understood immune dysfunction. Markers of a chronically activated immune system are closely linked to several complications of CKO and represent powerful predictors for mortality in the CKD population. On the other hand, CKD patients respond poorly to vaccination and to challenges such as bacterial infection. Interestingly, the main causes of death in patients with CKD are cardiovascular and infectious diseases, both being pathotogic processes closely linked to immune function. Therefore, accelerated tissue degeneration (as a consequence of chronic inflammation) and increased rate of sepsis (because of a poorly orchestrated immune response) represent the most important targets for interventions aiming to reduce mortality in CKD patients. Understanding the mechanisms behind the immune dysfunction that is peculiar to CKD generates a perspective to improve outcomes in this group of patients.

Original languageEnglish
JournalPeritoneal Dialysis International
Volume28
Issue numberSUPP. 3
Publication statusPublished - 01-06-2008
Externally publishedYes

Fingerprint

Uremia
Chronic Renal Insufficiency
Dialysis
Mortality
Bacterial Infections
Communicable Diseases
Cause of Death
Immune System
Sepsis
Vaccination
Cardiovascular Diseases
Inflammation
Population

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Hauser, A. B., Stinghen, A. E. M., Kato, S., Bucharles, S., Aita, C., Yuzawa, Y., & Pecoits-Filho, R. (2008). Characteristics and causes of immune dysfunction related to uremia and dialysis. Peritoneal Dialysis International, 28(SUPP. 3).
Hauser, Aline Borsato ; Stinghen, Andréa E M ; Kato, Sawako ; Bucharles, Sérgio ; Aita, Carlos ; Yuzawa, Yukio ; Pecoits-Filho, Roberto. / Characteristics and causes of immune dysfunction related to uremia and dialysis. In: Peritoneal Dialysis International. 2008 ; Vol. 28, No. SUPP. 3.
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Hauser, AB, Stinghen, AEM, Kato, S, Bucharles, S, Aita, C, Yuzawa, Y & Pecoits-Filho, R 2008, 'Characteristics and causes of immune dysfunction related to uremia and dialysis', Peritoneal Dialysis International, vol. 28, no. SUPP. 3.

Characteristics and causes of immune dysfunction related to uremia and dialysis. / Hauser, Aline Borsato; Stinghen, Andréa E M; Kato, Sawako; Bucharles, Sérgio; Aita, Carlos; Yuzawa, Yukio; Pecoits-Filho, Roberto.

In: Peritoneal Dialysis International, Vol. 28, No. SUPP. 3, 01.06.2008.

Research output: Contribution to journalArticle

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AU - Hauser, Aline Borsato

AU - Stinghen, Andréa E M

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AU - Yuzawa, Yukio

AU - Pecoits-Filho, Roberto

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AB - From the immunologic viewpoint, chronic kidney disease (CKD) is characterized by disorders of both the innate and adaptive systems, generating a complex and still not fully understood immune dysfunction. Markers of a chronically activated immune system are closely linked to several complications of CKO and represent powerful predictors for mortality in the CKD population. On the other hand, CKD patients respond poorly to vaccination and to challenges such as bacterial infection. Interestingly, the main causes of death in patients with CKD are cardiovascular and infectious diseases, both being pathotogic processes closely linked to immune function. Therefore, accelerated tissue degeneration (as a consequence of chronic inflammation) and increased rate of sepsis (because of a poorly orchestrated immune response) represent the most important targets for interventions aiming to reduce mortality in CKD patients. Understanding the mechanisms behind the immune dysfunction that is peculiar to CKD generates a perspective to improve outcomes in this group of patients.

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Hauser AB, Stinghen AEM, Kato S, Bucharles S, Aita C, Yuzawa Y et al. Characteristics and causes of immune dysfunction related to uremia and dialysis. Peritoneal Dialysis International. 2008 Jun 1;28(SUPP. 3).