TY - JOUR
T1 - Characteristics of adult patients newly diagnosed with Crohn’s disease
T2 - interim analysis of the nation-wide inception cohort registry study of patients with Crohn’s disease in Japan (iCREST-CD)
AU - Matsuoka, Katsuyoshi
AU - Fujii, Toshimitsu
AU - Okamoto, Ryuichi
AU - Yamada, Akihiro
AU - Kunisaki, Reiko
AU - Matsuura, Minoru
AU - Watanabe, Kenji
AU - Shiga, Hisashi
AU - Takatsu, Noritaka
AU - Bamba, Shigeki
AU - Mikami, Yohei
AU - Yamamoto, Takayuki
AU - Shimoyama, Takahiro
AU - Motoya, Satoshi
AU - Torisu, Takehiro
AU - Kobayashi, Taku
AU - Ohmiya, Naoki
AU - Saruta, Masayuki
AU - Matsuda, Koichiro
AU - Matsumoto, Takayuki
AU - Nakase, Hiroshi
AU - Maemoto, Atsuo
AU - Shinzaki, Shinichiro
AU - Murata, Yoko
AU - Yoshigoe, Shinichi
AU - Sasaki, Ayako
AU - Yajima, Tsutomu
AU - Hisamatsu, Tadakazu
N1 - Publisher Copyright:
© 2022, Japanese Society of Gastroenterology.
PY - 2022/11
Y1 - 2022/11
N2 - Background: The Inception Cohort Registry Study of Patients with Crohn’s Disease aimed to clarify clinical characteristics and disease course of newly diagnosed Crohn’s disease patients in Japan throughout a 4-year period. Results from an interim analysis of the largest nation-wide registry study that covers approximately 1% of Crohn’s disease patient population in Japan are reported. Methods: This prospective, observational registry study was conducted at 19 tertiary centers in Japan. Patients newly diagnosed with Crohn’s disease after June 2016 (age ≥ 16 years at informed consent) were enrolled between December 17, 2018 and June 30, 2020. Patient demographics, diagnostic procedures and categories, disease location and lesion behavior (Montreal classification) at the time of diagnosis were recorded. Results: Of 673 patients enrolled, 672 (99.9%) were analyzed (458: men, 214: women), male-to-female ratio: 2.1, median age at diagnosis 25 (range 13–86) years; peak age of disease diagnosis: 20–24 years. Most common disease location was L3 (ileocolonic; 60.1%). Non-stricturing, non-penetrating (B1) disease was most common behavior (62.8%); 48.9% reported perianal lesions. Notably, age-wise analysis revealed disease phenotypes varied between patients aged < 40 and ≥ 40 years in terms of male-to-female ratio (2.5/1.3)/disease location (L3: 66.3%/37.0%)/disease behavior (B1: 66.4%/50.0%)/perianal lesion: (55.7%/20.5%) at Crohn’s disease diagnosis, respectively. Conclusions: Interim analysis of this nation-wide Inception Cohort Registry Study of Patients with Crohn’s Disease revealed the demographics and disease characteristics of newly diagnosed Crohn’s disease patients in Japan and demonstrated that disease phenotype varied between patients aged < 40 and ≥ 40 years, serving as important information for management of individual patients.
AB - Background: The Inception Cohort Registry Study of Patients with Crohn’s Disease aimed to clarify clinical characteristics and disease course of newly diagnosed Crohn’s disease patients in Japan throughout a 4-year period. Results from an interim analysis of the largest nation-wide registry study that covers approximately 1% of Crohn’s disease patient population in Japan are reported. Methods: This prospective, observational registry study was conducted at 19 tertiary centers in Japan. Patients newly diagnosed with Crohn’s disease after June 2016 (age ≥ 16 years at informed consent) were enrolled between December 17, 2018 and June 30, 2020. Patient demographics, diagnostic procedures and categories, disease location and lesion behavior (Montreal classification) at the time of diagnosis were recorded. Results: Of 673 patients enrolled, 672 (99.9%) were analyzed (458: men, 214: women), male-to-female ratio: 2.1, median age at diagnosis 25 (range 13–86) years; peak age of disease diagnosis: 20–24 years. Most common disease location was L3 (ileocolonic; 60.1%). Non-stricturing, non-penetrating (B1) disease was most common behavior (62.8%); 48.9% reported perianal lesions. Notably, age-wise analysis revealed disease phenotypes varied between patients aged < 40 and ≥ 40 years in terms of male-to-female ratio (2.5/1.3)/disease location (L3: 66.3%/37.0%)/disease behavior (B1: 66.4%/50.0%)/perianal lesion: (55.7%/20.5%) at Crohn’s disease diagnosis, respectively. Conclusions: Interim analysis of this nation-wide Inception Cohort Registry Study of Patients with Crohn’s Disease revealed the demographics and disease characteristics of newly diagnosed Crohn’s disease patients in Japan and demonstrated that disease phenotype varied between patients aged < 40 and ≥ 40 years, serving as important information for management of individual patients.
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U2 - 10.1007/s00535-022-01907-2
DO - 10.1007/s00535-022-01907-2
M3 - Article
C2 - 35930087
AN - SCOPUS:85135471663
SN - 0944-1174
VL - 57
SP - 867
EP - 878
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
IS - 11
ER -