Characteristics of anal canal cancer in Japan

Kazutaka Yamada, Yasumitsu Saiki, Koji Komori, Akio Shiomi, Masashi Ueno, Masaaki Ito, Koya Hida, Seiichiro Yamamoto, Manabu Shiozawa, Soichiro Ishihara, Yukihide Kanemitsu, Hideki Ueno, Tatsuya Kinjo, Kotaro Maeda, Junichiro Kawamura, Fumihiko Fujita, Keiichi Takahashi, Tsunekazu Mizushima, Yasuhiro Shimada, Shin SasakiEiji Sunami, Fumio Ishida, Keiji Hirata, Shinobu Ohnuma, Kimihiko Funahashi, Jun Watanabe, Yusuke Kinugasa, Shigeki Yamaguchi, Yojiro Hashiguchi, Masataka Ikeda, Takeshi Sudo, Yoshito Komatsu, Keiji Koda, Kazuhiro Sakamoto, Masazumi Okajima, Hideyuki Ishida, Yuichi Hisamatsu, Taiki Masuda, Shinichiro Mori, Kazuhito Minami, Seiji Hasegawa, Shungo Endo, Akinori Iwashita, Madoka Hamada, Yoichi Ajioka, Koichiro Usuku, Tokunori Ikeda, Kenichi Sugihara

Research output: Contribution to journalArticlepeer-review

Abstract

Anal canal cancer (ACC) has been reported to be an uncommon cancer in Japan, as in the USA, Europe, and Australia. This retrospective multi-institutional study was conducted to clarify the characteristics of ACC in Japan. First, the histological ACC type cases treated between 1991 and 2015 were collected. A detailed analysis of the characteristics of anal canal squamous cell carcinoma (SCC) cases was then conducted. The results of the histological types revealed that of the 1781 ACC cases, 435 cases (24.4%) including seven cases of adenosquamous cell carcinomas were SCC and 1260 cases (70.7%) were adenocarcinoma. However, the most common histological type reported in the USA, Europe, and Australia is SCC. Most ACC cases are adenocarcinomas and there is a low incidence of SCC in Japan which is different from the above-mentioned countries. Moreover, we reclassified T4 into the following two groups based on tumor size: T4a (tumor diameter of 5 cm or less) and T4b (tumor diameter of more than 5 cm). The results of the TNM classification of SCC revealed that the hazard ratio (HR) to T1 of T2, T3, T4a, and T4b was 2.45, 2.28, 2.89, and 4.97, respectively. As T4b cases had a worse prognosis than T4a cases, we propose that T4 for anal canal SCC in Japan be subclassified into T4a and T4b.

Original languageEnglish
Pages (from-to)2735-2743
Number of pages9
JournalCancer Medicine
Volume11
Issue number14
DOIs
Publication statusPublished - 07-2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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