Characteristics of cerebral aneurysms in Japan

Fusao Ikawa, Toshikazu Hidaka, Michitsura Yoshiyama, Hideo Ohba, Shingo Matsuda, Iori Ozono, Koji Iihara, Hiroyuki Kinouchi, Kazuhiko Nozaki, Yoko Kato, Akio Morita, Nobuaki Michihata, Hideo Yasunaga, Kaoru Kurisu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The characteristics of cerebral aneurysms in Japan differ from other countries in the higher incidence of unruptured cerebral aneurysm detected by brain check-up screening, higher rupture rate of unruptured cerebral aneurysm, higher incidence of subarachnoid hemorrhage, and superior outcome after subarachnoid hemorrhage based on meta-analysis. Head shape, genetic features, environmental factors, demographics, and medical system in Japan are also different from other countries. Unruptured cerebral aneurysms are 2.8 times more likely to rupture in Japanese than western aneurysms, resulting in the highest incidence of subarachnoid hemorrhage in the world. The exact and specific mechanisms of de novo, growth, and rupture of cerebral aneurysms have not been elucidated. Investigations will contribute to the understanding of cerebral aneurysms and subarachnoid hemorrhage worldwide. Some features of cerebral aneurysm in Japan are discussed for possible research guidance in the elucidation of the predominance of subarachnoid hemorrhage in Japan.

Original languageEnglish
Pages (from-to)399-406
Number of pages8
Journalneurologia medico-chirurgica
Issue number11
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


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