Characteristics of muscarinic cholinergic, γ-aminobutyric acidA and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis

Kenshi Murase, Toshitaka Nabeshima, Tsutomu Kameyama, Masashi Sasa, Shuji Takaori, Hisamitsu Ujihara, Kumatoshi Ishihara, Junzo Yamada, Tadao Serikawa

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Characteristics of muscarinic cholinergic (mACh), γ-aminobutyric acidA (GABAA) and phencyclidine (PCP) receptors in the spontaneously epileptic rats (SER), which exhibit both absence-like seizures and tonic convulsion, were examined using in vitro quantitative autoradiography. Computer analysis using autoradiographic technique revealed that the amount of the specific binding of [3H]quinuclidinyl benzilate (QNB) to mACh receptors in the striatum of SER was more than that of zitter rats, not exhibiting both seizures and convulsion. However, the specific bindings of [3H]muscimol and [3H]N-(2-thienyl)cyclohexyl)3,4-piperidine (TCP) to GABAA and PCP receptors, respectively, of SER were not different from those of zitter rats in various regions tested. These results suggest that hyperfunction of mACh receptors in the striatum is involved in the appearance of absence-like seizures and tonic convulsion of SER.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume131
Issue number1
DOIs
Publication statusPublished - 30-09-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Characteristics of muscarinic cholinergic, γ-aminobutyric acid<sub>A</sub> and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis'. Together they form a unique fingerprint.

Cite this