TY - JOUR
T1 - Characteristics of patients with liver cancer in the BioBank Japan project
AU - BioBank Japan Cooperative Hospital Group
AU - Ukawa, Shigekazu
AU - Okada, Emiko
AU - Nakamura, Koshi
AU - Hirata, Makoto
AU - Nagai, Akiko
AU - Matsuda, Koichi
AU - Yamagata, Zentaro
AU - Kamatani, Yoichiro
AU - Ninomiya, Toshiharu
AU - Kiyohara, Yutaka
AU - Muto, Kaori
AU - Kubo, Michiaki
AU - Nakamura, Yusuke
AU - Tamakoshi, Akiko
AU - Harada, Hiromasa
AU - Kaneko, Kiyoshi
AU - Matsumoto, Shuichi
AU - Shiono, Masaki
AU - Minami, Shiro
AU - Yoshida, Hiroshi
AU - Taniai, Nobuhiko
AU - Watanabe, Sumio
AU - Fujiwara, Noriko
AU - Yamataka, Atsuyuki
AU - Asai, Satoshi
AU - Moriyama, Mitsuhiko
AU - Takahashi, Yasuo
AU - Fujioka, Tomoaki
AU - Obara, Wataru
AU - Mori, Seijiro
AU - Ito, Hideki
AU - Nagayama, Satoshi
AU - Miki, Yoshio
AU - Masumoto, Akihide
AU - Yamada, Akira
AU - Nishizawa, Yasuko
AU - Kodama, Ken
AU - Naka, Shigeyuki
AU - Endo, Yoshihiro
AU - Koretsune, Yukihiro
AU - Mita, Eiji
AU - Morimoto, Kozo
N1 - Publisher Copyright:
© 2017 The Authors.
PY - 2017
Y1 - 2017
N2 - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.
AB - Background: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. Methods: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated. Results: Of the 1354 patients with available liver cancer histology, 91.9% had hepatocellular carcinoma (HCC). Compared with the National Health and Nutrition Examination Survey, greater proportions of the male patients in this cohort were daily alcohol consumers (26%), and a greater proportion of the menwas overweight/obesity (22%). Although Japan is the only Asian country with a predominance of hepatitis C virus (HCV)-related HCC, the prevalence of HCV infection (44%) was lower than that in a previous study. The 3-, 5-, and 10-year cumulative survival rates were 57%, 47%, and 25% in men, respectively, and 49%, 41%, and 27% in women, respectively. Conclusions: The present results provide an overview of the patients with liver cancer in the BBJ project. We are planning further analyses combined with various high-throughput 'omics' technologies.
KW - Cohort Lifestyle
KW - Liver cancer
KW - Survival rate
KW - Tumor biomarkers
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U2 - 10.1016/j.je.2016.12.007
DO - 10.1016/j.je.2016.12.007
M3 - Article
C2 - 28214185
AN - SCOPUS:85016400213
SN - 0917-5040
VL - 27
SP - S43-S48
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 3
ER -