Characteristics of Transient Cerebral Ischemia-Induced Deficits on Various Learning and Memory Tasks in Male Mongolian Gerbils

Manabu Amano, Masaya Hasegawa, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We examined the characteristics of 5-min cerebral ischemia-induced behavioral deficits in spontaneous locomotor activity and their effects on the performance of habituation (HAB), passive avoidance (PA) and 8-arm radial maze (RM) tasks in Mongolian gerbils. Performances in HAB, PA and RM were impaired within 2 days after occlusion, and gerbils showed hyperlocomotion during this period. Ten days after ischemia, the hyperlocomotion disappeared and performance in the HAB and PA was the same as that in the sham-operated group. Retention in the RM was impaired at that period, but this impairment was overcome, and retention recovered easily to the sham-operated level with a few additional trials. When the acquisition trial in the RM began at 11 days after occlusion, severe learning impairment was found. Destruction of hippocampal CAl neurons appears from 2-3 days after ischemic insult, with most CAl neurons having disappeared by day 7. These findings suggest that the impairment of performance in the HAB and PA within 2 days after occlusion may be related to an early phase of CAl neuronal death and to hyperlocomotion, although the impairment of spatial learning and memory was clearly associated with CAl injury 10 days after ischemia.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalThe Japanese Journal of Pharmacology
Volume63
Issue number4
DOIs
Publication statusPublished - 01-01-1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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