TY - JOUR
T1 - Characterization of an unusual DS-1-like G8P[8] rotavirus strain from Japan in 2017
T2 - Evolution of emerging DS-1-like G8P[8] strains through reassortment
AU - Kamiya, Hajime
AU - Tacharoenmuang, Ratana
AU - Ide, Tomihiko
AU - Negoro, Manami
AU - Tanaka, Takaaki
AU - Asada, Kazutoyo
AU - Nakamura, Haruna
AU - Sugiura, Katsumi
AU - Umemoto, Masakazu
AU - Kuroki, Haruo
AU - Ito, Hiroaki
AU - Tanaka, Shigeki
AU - Ito, Mitsue
AU - Fukuda, Saori
AU - Hatazawa, Riona
AU - Hara, Yuya
AU - Guntapong, Ratigorn
AU - Murata, Takayuki
AU - Taniguchi, Kiyosu
AU - Suga, Shigeru
AU - Nakano, Takashi
AU - Taniguchi, Koki
AU - Komoto, Satoshi
N1 - Funding Information:
Space limitations preclude the inclusion as authors of the following members of the Rotavirus Epidemiology Study Group: Drs. Toshiaki Ihara and Takao Fujisawa, and Ms. Maiko Kinoshita (National Mie Hospital), Dr. Masaru Ido (Mie Chuo Medical Center), and Drs. Masamune Higashikawa, Takashi Fujiwara, and Ryoji Ichimi (Japanese Red Cross Ise Hospital). This study was supported in part by the Research on Regulatory Science of Pharmaceuticals and Medical Devices from the Japan Agency for Medical Research and Development (17fk0108215h0002), AMED (SK).
Publisher Copyright:
© 2019, National Institute of Health. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses with a bovinelike G8 genotype (DS-1-like G8P[8] strains) has been reported in several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P[8] strain (RVA/Human-wt/JPN/ SO1162/2017/G8P[8]) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation, including genes from both genogroup 1 and 2: G8-P[8]-I2-R2- C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P[8] strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of previously reported DS-1-like G8P[8] strains. Thus, SO1162 was suggested to be a reassortant strain that acquired the VP1 gene from Southeast Asian DS-1-like G1P[8] strains on the genetic background of co-circulating DS-1-like G8P[8] strains. Our findings provide important insights into the evolutionary dynamics of emerging DS-1-like G8P[8] strains.
AB - The emergence of unusual DS-1-like intergenogroup reassortant rotaviruses with a bovinelike G8 genotype (DS-1-like G8P[8] strains) has been reported in several Asian countries. During the rotavirus surveillance program in Japan in 2017, a DS-1-like G8P[8] strain (RVA/Human-wt/JPN/ SO1162/2017/G8P[8]) was identified in 43 rotavirus-positive stool samples. Strain SO1162 was shown to have a unique genotype constellation, including genes from both genogroup 1 and 2: G8-P[8]-I2-R2- C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP1 gene of strain SO1162 appeared to have originated from DS-1-like G1P[8] strains from Thailand and Vietnam, while the remaining 10 genes were closely related to those of previously reported DS-1-like G8P[8] strains. Thus, SO1162 was suggested to be a reassortant strain that acquired the VP1 gene from Southeast Asian DS-1-like G1P[8] strains on the genetic background of co-circulating DS-1-like G8P[8] strains. Our findings provide important insights into the evolutionary dynamics of emerging DS-1-like G8P[8] strains.
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U2 - 10.7883/yoken.JJID.2018.484
DO - 10.7883/yoken.JJID.2018.484
M3 - Article
C2 - 30814461
AN - SCOPUS:85070516875
SN - 1344-6304
VL - 72
SP - 256
EP - 260
JO - Japanese journal of infectious diseases
JF - Japanese journal of infectious diseases
IS - 4
ER -