Characterization of genes conferring resistance against ISP-1/myriocin-induced sphingolipid depletion in yeast

Hiromu Takematsu, Yasunori Kozutsumi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

ISP-1 is a naturally occurring immunosuppressant with a structure resembling that of sphingosine. ISP-1 inhibits serine palmitoyltransferase, the primary enzyme of sphingolipid biosynthesis and reduces intracellular sphingolipid, leading to cell death in mammalian cells and in yeast cells. To determine the mechanism underlying cell death induced by sphingolipid deprivation, ISP-1 resistant genes were isolated and characterized in yeast. Two genes were found to be tightly associated with sphingolipid signaling.

Original languageEnglish
Title of host publicationSphingolipid Biology
PublisherSpringer Japan
Pages463-474
Number of pages12
ISBN (Print)4431341986, 9784431341987
DOIs
Publication statusPublished - 01-12-2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Characterization of genes conferring resistance against ISP-1/myriocin-induced sphingolipid depletion in yeast'. Together they form a unique fingerprint.

  • Cite this