Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS

Ryuichi Iida, Kiyofumi Yamada, Takayoshi Mamiya, Kuniaki Saito, Mitsuru Seishima, Toshitaka Nabeshima

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Abstract

Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BMS. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP- BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalJournal of Neuroimmunology
Volume95
Issue number1-2
DOIs
Publication statusPublished - 01-03-1999

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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