Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS

Ryuichi Iida, Kiyofumi Yamada, Takayoshi Mamiya, Kuniaki Saito, Mitsuru Seishima, Toshitaka Nabeshima

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BMS. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP- BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalJournal of Neuroimmunology
Volume95
Issue number1-2
DOIs
Publication statusPublished - 01-03-1999
Externally publishedYes

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Murine Acquired Immunodeficiency Syndrome
Memory Disorders
Inbred C57BL Mouse
Learning
Water
Maze Learning
Reversal Learning
AIDS Dementia Complex
Murine Leukemia Viruses
Vision Disorders
Immunosuppressive Agents
Visual Fields
Immunosuppression
Cognition

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Iida, Ryuichi ; Yamada, Kiyofumi ; Mamiya, Takayoshi ; Saito, Kuniaki ; Seishima, Mitsuru ; Nabeshima, Toshitaka. / Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS. In: Journal of Neuroimmunology. 1999 ; Vol. 95, No. 1-2. pp. 65-72.
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Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS. / Iida, Ryuichi; Yamada, Kiyofumi; Mamiya, Takayoshi; Saito, Kuniaki; Seishima, Mitsuru; Nabeshima, Toshitaka.

In: Journal of Neuroimmunology, Vol. 95, No. 1-2, 01.03.1999, p. 65-72.

Research output: Contribution to journalArticle

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