Characterization of myeloid neoplasms following allogeneic hematopoietic cell transplantation

on behalf of the Japan Society for Hematopoietic Cell Transplantation Late Effects and Quality of Life Working Group

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We compared characteristics of myeloid neoplasms (MNs) following allogeneic hematopoietic cell transplantation (HCT) versus autologous HCT using a Japanese HCT registry database. Among 43 788 patients who underwent allogeneic (n = 18 874) or autologous HCT (n = 24 914) for non-myeloid malignancies or non-malignant diseases, 352 developed MNs. The cumulative incidence of MNs was lower after allogeneic HCT than after autologous HCT (0.3% vs. 1.8% at 10 years, respectively, p <.001). Compared with autologous HCT, MNs following allogeneic HCT developed in younger patients (median, 42 vs. 57 years old, respectively) and sooner after HCT (median, 16 vs. 33 months, respectively). Approximately half of MNs following allogeneic HCT were donor-derived and occurred later than recipient-derived MNs (median, 26 vs. 6 months, respectively, p =.003). In multivariate analysis, reduced-intensity conditioning and cord blood transplantation were associated with MN development after allogeneic HCT. Overall survival was similar in patients who developed MNs following allogeneic versus autologous HCT (18% vs. 22% at 5 years, respectively, p =.48). Patient age ≥ 55 years, the presence of previous HCT, AML subtype, and chromosome 5 or 7 abnormalities were adverse factors for overall survival after MN diagnosis. Further research is warranted to elucidate the mechanisms of MN development following allogeneic HCT.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalAmerican Journal of Hematology
Issue number2
Publication statusPublished - 01-02-2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hematology


Dive into the research topics of 'Characterization of myeloid neoplasms following allogeneic hematopoietic cell transplantation'. Together they form a unique fingerprint.

Cite this