TY - JOUR
T1 - Characterization of the human herpesvirus 6A U23 gene
AU - Hayashi, Mayuko
AU - Yoshida, Kento
AU - Tang, Huamin
AU - Sadaoka, Tomohiko
AU - Kawabata, Akiko
AU - Jasirwan, Chyntia
AU - Mori, Yasuko
PY - 2014/2
Y1 - 2014/2
N2 - Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A-infected cells. The results indicated that the U23 protein was expressed at the late phase of infection as a glycoprotein, but was not incorporated into virions, and mostly stayed within the trans Golgi network (TGN) in HHV-6A-infected cells. Furthermore, analysis using a U23-defective mutant virus showed that the gene is nonessential for viral replication in vitro.
AB - Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A-infected cells. The results indicated that the U23 protein was expressed at the late phase of infection as a glycoprotein, but was not incorporated into virions, and mostly stayed within the trans Golgi network (TGN) in HHV-6A-infected cells. Furthermore, analysis using a U23-defective mutant virus showed that the gene is nonessential for viral replication in vitro.
UR - http://www.scopus.com/inward/record.url?scp=84890874122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890874122&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2013.12.004
DO - 10.1016/j.virol.2013.12.004
M3 - Article
C2 - 24503071
AN - SCOPUS:84890874122
SN - 0042-6822
VL - 450-451
SP - 98
EP - 105
JO - Virology
JF - Virology
ER -