TY - JOUR
T1 - Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA
AU - Yamada, Kouji
AU - Ichino, Naohiro
AU - Nishii, Kazuhiro
AU - Sawada, Hirohide
AU - Higashiyama, Shigeki
AU - Ishiguro, Hiroshi
AU - Nagatsu, Toshiharu
N1 - Funding Information:
This work was supported by a grant-in-aid from Fujita Health University.
PY - 2000/9/5
Y1 - 2000/9/5
N2 - NTAK (neural- and thymus-derived activator for the ErbB kinase, neuregulin-2) is a novel member of the epidermal growth factor (EGF) family. We have isolated and characterized the human NTAK gene, comprising 12 exons spanning in excess of 55 kilobases (kb). The 7.0 kb long mRNA of the human NTAK gene was expressed in the human neuroblastoma SK-N-SH cell line with two alternative isoforms detected. Furthermore, six isoforms have been identified from rat brain and PC-12 cells. Although the α isoform of the NTAK gene was found to be expressed in all tissues including brain, the β isoform was expressed only in rat brain tissues. Potential regulatory regions included consensus binding sites for AP-2, TF-IIIA, Sp-1, and YY-1 located in the 5'- flanking region of the NTAK gene. (C) 2000 Elsevier Science B.V.
AB - NTAK (neural- and thymus-derived activator for the ErbB kinase, neuregulin-2) is a novel member of the epidermal growth factor (EGF) family. We have isolated and characterized the human NTAK gene, comprising 12 exons spanning in excess of 55 kilobases (kb). The 7.0 kb long mRNA of the human NTAK gene was expressed in the human neuroblastoma SK-N-SH cell line with two alternative isoforms detected. Furthermore, six isoforms have been identified from rat brain and PC-12 cells. Although the α isoform of the NTAK gene was found to be expressed in all tissues including brain, the β isoform was expressed only in rat brain tissues. Potential regulatory regions included consensus binding sites for AP-2, TF-IIIA, Sp-1, and YY-1 located in the 5'- flanking region of the NTAK gene. (C) 2000 Elsevier Science B.V.
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U2 - 10.1016/S0378-1119(00)00309-7
DO - 10.1016/S0378-1119(00)00309-7
M3 - Article
C2 - 10974560
AN - SCOPUS:0034609447
SN - 0378-1119
VL - 255
SP - 15
EP - 24
JO - Gene
JF - Gene
IS - 1
ER -