Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Mark A.G. Eldridge; Walter Lerchner; Richard C. Saunders; Hiroyuki Kaneko; Kristopher W. Krausz; Frank J. Gonzalez; Bin Ji; Makoto Higuchi; Takafumi Minamimoto; Barry J. Richmond

doi:10.1038/nn.4192

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Mark A.G. Eldridge
, Walter Lerchner
, Richard C. Saunders
, Hiroyuki Kaneko
, Kristopher W. Krausz
, Frank J. Gonzalez
, Bin Ji
, Makoto Higuchi
, Takafumi Minamimoto
, Barry J. Richmond

Research output: Contribution to journal › Article › peer-review

115 Citations (Scopus)

Abstract

To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

Original language	English
Pages (from-to)	37-39
Number of pages	3
Journal	Nature Neuroscience
Volume	19
Issue number	1
DOIs	https://doi.org/10.1038/nn.4192
Publication status	Published - 29-12-2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1038/nn.4192

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title = "Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value",

abstract = "To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.",

author = "Eldridge, \{Mark A.G.\} and Walter Lerchner and Saunders, \{Richard C.\} and Hiroyuki Kaneko and Krausz, \{Kristopher W.\} and Gonzalez, \{Frank J.\} and Bin Ji and Makoto Higuchi and Takafumi Minamimoto and Richmond, \{Barry J.\}",

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AU - Eldridge, Mark A.G.

AU - Lerchner, Walter

AU - Saunders, Richard C.

AU - Kaneko, Hiroyuki

AU - Krausz, Kristopher W.

AU - Gonzalez, Frank J.

AU - Ji, Bin

AU - Higuchi, Makoto

AU - Minamimoto, Takafumi

AU - Richmond, Barry J.

PY - 2015/12/29

Y1 - 2015/12/29

N2 - To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

AB - To study how the interaction between orbitofrontal (OFC) and rhinal (Rh) cortices influences the judgment of reward size, we reversibly disconnected these regions using hM4Di-DREADD (designer receptor exclusively activated by designer drug). Repeated inactivation reduced sensitivity to differences in reward size in two monkeys. These results suggest that retrieval of relative stimulus values from memory depends on the interaction between Rh and OFC.

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Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

Abstract

All Science Journal Classification (ASJC) codes

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