Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates: A concise review

Hlaing Myat Thu, Theingi Win Myat, Mo Mo Win, Kyaw Zin Thant, Shofiqur Rahman, Kouji Umeda, Sa Van Nguyen, Faustino C. Icatlo, Kyoko Moriguchi, Koki Taniguchi, Takao Tsuji, Keiji Oguma, Sang Jong Kim, Hyun Suk Bae, Hyuk Joon Choi

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double- blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalKorean Journal for Food Science of Animal Resources
Volume37
Issue number1
DOIs
Publication statusPublished - 01-02-2017

Fingerprint

immunoglobulin Y
Egg Yolk
chicken eggs
Rotavirus
egg yolk
Chickens
Diarrhea
diarrhea
disease control
neonates
antibodies
Antibodies
Rotavirus Infections
Newborn Infant
Therapeutics
Placebos
Clinical Trials
placebos
Newborn Animals
clinical trials

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology

Cite this

Thu, Hlaing Myat ; Myat, Theingi Win ; Win, Mo Mo ; Thant, Kyaw Zin ; Rahman, Shofiqur ; Umeda, Kouji ; Van Nguyen, Sa ; Icatlo, Faustino C. ; Moriguchi, Kyoko ; Taniguchi, Koki ; Tsuji, Takao ; Oguma, Keiji ; Kim, Sang Jong ; Bae, Hyun Suk ; Choi, Hyuk Joon. / Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates : A concise review. In: Korean Journal for Food Science of Animal Resources. 2017 ; Vol. 37, No. 1. pp. 1-9.
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abstract = "The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double- blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.",
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Thu, HM, Myat, TW, Win, MM, Thant, KZ, Rahman, S, Umeda, K, Van Nguyen, S, Icatlo, FC, Moriguchi, K, Taniguchi, K, Tsuji, T, Oguma, K, Kim, SJ, Bae, HS & Choi, HJ 2017, 'Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates: A concise review', Korean Journal for Food Science of Animal Resources, vol. 37, no. 1, pp. 1-9. https://doi.org/10.5851/kosfa.2017.37.1.1

Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates : A concise review. / Thu, Hlaing Myat; Myat, Theingi Win; Win, Mo Mo; Thant, Kyaw Zin; Rahman, Shofiqur; Umeda, Kouji; Van Nguyen, Sa; Icatlo, Faustino C.; Moriguchi, Kyoko; Taniguchi, Koki; Tsuji, Takao; Oguma, Keiji; Kim, Sang Jong; Bae, Hyun Suk; Choi, Hyuk Joon.

In: Korean Journal for Food Science of Animal Resources, Vol. 37, No. 1, 01.02.2017, p. 1-9.

Research output: Contribution to journalReview article

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T1 - Chicken egg yolk antibodies (IgY) for prophylaxis and treatment of rotavirus diarrhea in human and animal neonates

T2 - A concise review

AU - Thu, Hlaing Myat

AU - Myat, Theingi Win

AU - Win, Mo Mo

AU - Thant, Kyaw Zin

AU - Rahman, Shofiqur

AU - Umeda, Kouji

AU - Van Nguyen, Sa

AU - Icatlo, Faustino C.

AU - Moriguchi, Kyoko

AU - Taniguchi, Koki

AU - Tsuji, Takao

AU - Oguma, Keiji

AU - Kim, Sang Jong

AU - Bae, Hyun Suk

AU - Choi, Hyuk Joon

PY - 2017/2/1

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N2 - The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double- blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.

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