Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1

Mohamed Hamed Hussein, Takashi Hashimoto, Tatsuya Suzuki, Ghada Abdel Hamid Daoud, Tatenobu Goto, Yoko Nakajima, Takazumi Kato, Masahito Hibi, Hirokazu Tomishige, Fujio Hara, Shin Kato, Hiroki Kakita, Michi Kamei, Tetsuya Ito, Ineko Kato, Atsushi Sugioka, Hajime Togari

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Abstract

Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status Pduring their regular outpatient follow-up visits. A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-β1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.5-15 years old) who received living-related liver transplantation due to inherited metabolic diseases (n=6; in the form of propionic acidemia [n=1], methylmalonic acidemia [n=1], arginase deficiency [n=1], tyrosinemia [n=2], and glycogen storage disease type 1b [n=1], with an age range of 2.4-14.6 years old) and due to biliary atresia ([n=10], with an age range of 2.9-14.5 years old). Serum oxidative stress index, complement component-5a, and transforming growth factor-β1 were significantly higher in the inherited metabolic diseases group than in the biliary atresia group. In all patients, serum oxidative stress index correlated positively with complement component-5a and transforming growth factor-β1. Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-β1.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalAnnals of Transplantation
Volume18
Issue number1
DOIs
Publication statusPublished - 08-05-2013

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Metabolic Diseases
Transforming Growth Factors
Liver Transplantation
Oxidative Stress
Complement C5a
Serum
Biliary Atresia
Therapeutics
Hyperargininemia
Outpatients
Propionic Acidemia
Tyrosinemias
Glycogen Storage Disease Type II
Pediatrics
Oxidants
Liver Cirrhosis
Hydrogen Peroxide
Antioxidants
Population

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Hussein, Mohamed Hamed ; Hashimoto, Takashi ; Suzuki, Tatsuya ; Daoud, Ghada Abdel Hamid ; Goto, Tatenobu ; Nakajima, Yoko ; Kato, Takazumi ; Hibi, Masahito ; Tomishige, Hirokazu ; Hara, Fujio ; Kato, Shin ; Kakita, Hiroki ; Kamei, Michi ; Ito, Tetsuya ; Kato, Ineko ; Sugioka, Atsushi ; Togari, Hajime. / Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1. In: Annals of Transplantation. 2013 ; Vol. 18, No. 1. pp. 63-68.
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title = "Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1",
abstract = "Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status Pduring their regular outpatient follow-up visits. A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-β1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.5-15 years old) who received living-related liver transplantation due to inherited metabolic diseases (n=6; in the form of propionic acidemia [n=1], methylmalonic acidemia [n=1], arginase deficiency [n=1], tyrosinemia [n=2], and glycogen storage disease type 1b [n=1], with an age range of 2.4-14.6 years old) and due to biliary atresia ([n=10], with an age range of 2.9-14.5 years old). Serum oxidative stress index, complement component-5a, and transforming growth factor-β1 were significantly higher in the inherited metabolic diseases group than in the biliary atresia group. In all patients, serum oxidative stress index correlated positively with complement component-5a and transforming growth factor-β1. Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-β1.",
author = "Hussein, {Mohamed Hamed} and Takashi Hashimoto and Tatsuya Suzuki and Daoud, {Ghada Abdel Hamid} and Tatenobu Goto and Yoko Nakajima and Takazumi Kato and Masahito Hibi and Hirokazu Tomishige and Fujio Hara and Shin Kato and Hiroki Kakita and Michi Kamei and Tetsuya Ito and Ineko Kato and Atsushi Sugioka and Hajime Togari",
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Hussein, MH, Hashimoto, T, Suzuki, T, Daoud, GAH, Goto, T, Nakajima, Y, Kato, T, Hibi, M, Tomishige, H, Hara, F, Kato, S, Kakita, H, Kamei, M, Ito, T, Kato, I, Sugioka, A & Togari, H 2013, 'Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1', Annals of Transplantation, vol. 18, no. 1, pp. 63-68. https://doi.org/10.12659/AOT.883820

Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1. / Hussein, Mohamed Hamed; Hashimoto, Takashi; Suzuki, Tatsuya; Daoud, Ghada Abdel Hamid; Goto, Tatenobu; Nakajima, Yoko; Kato, Takazumi; Hibi, Masahito; Tomishige, Hirokazu; Hara, Fujio; Kato, Shin; Kakita, Hiroki; Kamei, Michi; Ito, Tetsuya; Kato, Ineko; Sugioka, Atsushi; Togari, Hajime.

In: Annals of Transplantation, Vol. 18, No. 1, 08.05.2013, p. 63-68.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-β1

AU - Hussein, Mohamed Hamed

AU - Hashimoto, Takashi

AU - Suzuki, Tatsuya

AU - Daoud, Ghada Abdel Hamid

AU - Goto, Tatenobu

AU - Nakajima, Yoko

AU - Kato, Takazumi

AU - Hibi, Masahito

AU - Tomishige, Hirokazu

AU - Hara, Fujio

AU - Kato, Shin

AU - Kakita, Hiroki

AU - Kamei, Michi

AU - Ito, Tetsuya

AU - Kato, Ineko

AU - Sugioka, Atsushi

AU - Togari, Hajime

PY - 2013/5/8

Y1 - 2013/5/8

N2 - Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status Pduring their regular outpatient follow-up visits. A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-β1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.5-15 years old) who received living-related liver transplantation due to inherited metabolic diseases (n=6; in the form of propionic acidemia [n=1], methylmalonic acidemia [n=1], arginase deficiency [n=1], tyrosinemia [n=2], and glycogen storage disease type 1b [n=1], with an age range of 2.4-14.6 years old) and due to biliary atresia ([n=10], with an age range of 2.9-14.5 years old). Serum oxidative stress index, complement component-5a, and transforming growth factor-β1 were significantly higher in the inherited metabolic diseases group than in the biliary atresia group. In all patients, serum oxidative stress index correlated positively with complement component-5a and transforming growth factor-β1. Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-β1.

AB - Main indications for liver transplantation in the pediatric population include biliary atresia and inherited metabolic diseases. The present study evaluated whether there are differences between pediatric patients undergoing living-related liver transplantation due to the two diseases in terms of their oxidative and immunological status Pduring their regular outpatient follow-up visits. A clinical outpatient study measuring serum oxidative stress index (calculated as serum oxidant/antioxidant ratio, in the form of serum total hydroperoxide/serum biological antioxidative potential), serum terminal complement component 5a, as an indicator of complement activity and immunological status, and transforming growth factor-β1, as a marker of liver fibrosis, in 16 patients (6 males and 10 females, 2.5-15 years old) who received living-related liver transplantation due to inherited metabolic diseases (n=6; in the form of propionic acidemia [n=1], methylmalonic acidemia [n=1], arginase deficiency [n=1], tyrosinemia [n=2], and glycogen storage disease type 1b [n=1], with an age range of 2.4-14.6 years old) and due to biliary atresia ([n=10], with an age range of 2.9-14.5 years old). Serum oxidative stress index, complement component-5a, and transforming growth factor-β1 were significantly higher in the inherited metabolic diseases group than in the biliary atresia group. In all patients, serum oxidative stress index correlated positively with complement component-5a and transforming growth factor-β1. Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-β1.

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