Chlamydia pneumoniae infection enhances lectin-like oxidized low-density lipoprotein receptor (LOX-1) expression on human endothelial cells

Tomoaki Yoshida, Naoki Koide, Isamu Mori, Hiroyasu Ito, Takashi Yokochi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Many studies indicate that Chlamydia pneumoniae infection is a crucial risk factor in atherogenesis. The most relevant cell type for the pathogenesis is the macrophage, which possesses classical scavenger receptors that uptake oxidized low-density lipoprotein (LDL). Here, a direct involvement of vascular endothelial cells in atherogenesis was examined employing in vitro infection of human umbilical vein endothelial cells (HUVEC) with C. pneumoniae. Chlamydia pneumoniae infection greatly enhanced the uptake of oxidized LDL, but not of acetylated LDL, by HUVEC. Among the scavenger receptors analyzed, LOX-1 transcription, which prefers oxidized LDL to acetylated LDL, was significantly amplified.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalFEMS Microbiology Letters
Volume260
Issue number1
DOIs
Publication statusPublished - 07-2006

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

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