Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan

BioBank Japan Cooperative Hospital Group

Research output: Contribution to journalArticle

Abstract

Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia. Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles. Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19e44 years, body mass index 18.5e22 kg/m2, glycated haemoglobin A1c < 6.0%, never smoker, chronic respiratory disease as a comorbidity and no medication use. Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.

Original languageEnglish
Pages (from-to)S77-S83
JournalJournal of epidemiology
Volume27
Issue number3
DOIs
Publication statusPublished - 01-01-2017

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Comorbidity
Japan
Cholesterol
Dyslipidemias
Serum
Glycosylated Hemoglobin A
LDL Cholesterol
Body Mass Index
HDL Cholesterol
Drinking
Triglycerides
Chronic Disease
Cardiovascular Diseases
Smoking
Guidelines
Blood Pressure
Therapeutics

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

BioBank Japan Cooperative Hospital Group. / Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities : BioBank Japan. In: Journal of epidemiology. 2017 ; Vol. 27, No. 3. pp. S77-S83.
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abstract = "Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia. Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles. Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19e44 years, body mass index 18.5e22 kg/m2, glycated haemoglobin A1c < 6.0{\%}, never smoker, chronic respiratory disease as a comorbidity and no medication use. Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.",
author = "{BioBank Japan Cooperative Hospital Group} and Hiroshi Yokomichi and Hokuto Noda and Akiko Nagai and Makoto Hirata and Akiko Tamakoshi and Yoichiro Kamatani and Yutaka Kiyohara and Koichi Matsuda and Kaori Muto and Toshiharu Ninomiya and Michiaki Kubo and Yusuke Nakamura and Zentaro Yamagata and Kazuo Misumi and Michiaki Kubo and Sunao Matsubayashi and Kei Matsuura and Shiro Minami and Hitoshi Sugihara and Eitaro Kodani and Naoto Tamura and Masakazu Matsushita and Akihiko Gotoh and Satoshi Asai and Mitsuhiko Moriyama and Yasuo Takahashi and Tomoaki Fujioka and Wataru Obara and Seijiro Mori and Hideki Ito and Satoshi Nagayama and Yoshio Miki and Akihide Masumoto and Akira Yamada and Yasuko Nishizawa and Ken Kodama and Satoshi Ugi and Hiroshi Maegawa and Yukihiro Koretsune and Hideo Kusuoka and Masao Okumura",
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Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities : BioBank Japan. / BioBank Japan Cooperative Hospital Group.

In: Journal of epidemiology, Vol. 27, No. 3, 01.01.2017, p. S77-S83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities

T2 - BioBank Japan

AU - BioBank Japan Cooperative Hospital Group

AU - Yokomichi, Hiroshi

AU - Noda, Hokuto

AU - Nagai, Akiko

AU - Hirata, Makoto

AU - Tamakoshi, Akiko

AU - Kamatani, Yoichiro

AU - Kiyohara, Yutaka

AU - Matsuda, Koichi

AU - Muto, Kaori

AU - Ninomiya, Toshiharu

AU - Kubo, Michiaki

AU - Nakamura, Yusuke

AU - Yamagata, Zentaro

AU - Misumi, Kazuo

AU - Kubo, Michiaki

AU - Matsubayashi, Sunao

AU - Matsuura, Kei

AU - Minami, Shiro

AU - Sugihara, Hitoshi

AU - Kodani, Eitaro

AU - Tamura, Naoto

AU - Matsushita, Masakazu

AU - Gotoh, Akihiko

AU - Asai, Satoshi

AU - Moriyama, Mitsuhiko

AU - Takahashi, Yasuo

AU - Fujioka, Tomoaki

AU - Obara, Wataru

AU - Mori, Seijiro

AU - Ito, Hideki

AU - Nagayama, Satoshi

AU - Miki, Yoshio

AU - Masumoto, Akihide

AU - Yamada, Akira

AU - Nishizawa, Yasuko

AU - Kodama, Ken

AU - Ugi, Satoshi

AU - Maegawa, Hiroshi

AU - Koretsune, Yukihiro

AU - Kusuoka, Hideo

AU - Okumura, Masao

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia. Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles. Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19e44 years, body mass index 18.5e22 kg/m2, glycated haemoglobin A1c < 6.0%, never smoker, chronic respiratory disease as a comorbidity and no medication use. Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.

AB - Background: Controlling serum cholesterol is critical to prevent cardiovascular disease in patients with dyslipidaemia. Guidelines emphasise the need to select treatment for dyslipidaemia based on specific patient profiles; however, there is little information about the serum cholesterol levels of patients in each profile in Japan. Therefore, we aimed to describe the serum cholesterol levels and prevalence of uncontrolled cases in Japanese patients with dyslipidaemia. Methods: We included data for patients with dyslipidaemia between 2003 and 2007 from the BioBank Japan Project (66 hospitals). Then, we reported their serum cholesterol levels by age, body mass index, glycaemic control (glycated haemoglobin A1c), blood pressure, smoking, drinking, comorbidity and medication profiles. Results: We included 22,189 male and 21,545 female patients. The mean serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and non-HDL-C levels in males were 117.4 mg/dL, 51.0 mg/dL, 187.6 mg/dL and 153.6 mg/dL, respectively; the corresponding levels in females were 129.5 mg/dL, 60.5 mg/dL, 144.9 mg/dL and 157.9 mg/dL, respectively. In both males and females, the LDL-C levels were the highest in the following profiles: age 19e44 years, body mass index 18.5e22 kg/m2, glycated haemoglobin A1c < 6.0%, never smoker, chronic respiratory disease as a comorbidity and no medication use. Conclusions: These data provide details of serum cholesterol levels by risk-factor profile in patients with dyslipidaemia and could add evidence of treatment decisions.

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U2 - 10.1016/j.je.2016.12.014

DO - 10.1016/j.je.2016.12.014

M3 - Article

C2 - 28196738

AN - SCOPUS:85016439475

VL - 27

SP - S77-S83

JO - Journal of Epidemiology

JF - Journal of Epidemiology

SN - 0917-5040

IS - 3

ER -