Chorea-acanthocytosis with polyclonal antibodies to ganglioside GM1

Mikio Hirayama, Tadanori Hamano, Masayuki Shiratori, Tatsuro Mutoh, Takanori Kumano, Takashi Aita, Masaru Kuriyama

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9 Citations (Scopus)


A patient with chorea-acanthocytosis presenting with axonal neuropathy showed an elevation in IgM polyclonal antibodies to the GM1 ganglioside, which were estimated by enzyme-linked immunosorbent assay and complement- mediated liposome immune lysis assay (LILA). This is the first demonstration of such antibodies in chorea-acanthocytosis. Anti-GM1 antibodies might have directly caused the axonal neuropathy by binding to GM1 or cross-reactive antigens in the nerves.

Original languageEnglish
Pages (from-to)23-24
Number of pages2
JournalJournal of the Neurological Sciences
Issue number1
Publication statusPublished - 03-10-1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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