Chromatin regulation by AML1 complex

Hitoshi Yoshida; Issay Kitabayashi

doi:10.1007/s12185-007-0004-0

Chromatin regulation by AML1 complex

Hitoshi Yoshida, Issay Kitabayashi

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

The AML1 gene is the most frequent target of chromosomal translocations in acute leukemias. AML1 is essential for definitive hematopoiesis and regulates transcription of its target genes by binding to the specific DNA sequence. AML1 forms large multiprotein complexes including CBFβ as a "core component" as well as several classes of chromatin modulators such as p300/CBP, MOZ, PML and HIPK2 as "regulatory complex". In this review, we describe the mechanisms by which AML1 complex regulates gene transcription and hematopoiesis, and its disruption by the leukemia-associated chromosomal translocations that affect genes for components of AML1 complex in view of deregulation of chromatin structure.

Original language	English
Pages (from-to)	19-24
Number of pages	6
Journal	International Journal of Hematology
Volume	87
Issue number	1
DOIs	https://doi.org/10.1007/s12185-007-0004-0
Publication status	Published - 01-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

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10.1007/s12185-007-0004-0

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abstract = "The AML1 gene is the most frequent target of chromosomal translocations in acute leukemias. AML1 is essential for definitive hematopoiesis and regulates transcription of its target genes by binding to the specific DNA sequence. AML1 forms large multiprotein complexes including CBFβ as a {"}core component{"} as well as several classes of chromatin modulators such as p300/CBP, MOZ, PML and HIPK2 as {"}regulatory complex{"}. In this review, we describe the mechanisms by which AML1 complex regulates gene transcription and hematopoiesis, and its disruption by the leukemia-associated chromosomal translocations that affect genes for components of AML1 complex in view of deregulation of chromatin structure.",

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AB - The AML1 gene is the most frequent target of chromosomal translocations in acute leukemias. AML1 is essential for definitive hematopoiesis and regulates transcription of its target genes by binding to the specific DNA sequence. AML1 forms large multiprotein complexes including CBFβ as a "core component" as well as several classes of chromatin modulators such as p300/CBP, MOZ, PML and HIPK2 as "regulatory complex". In this review, we describe the mechanisms by which AML1 complex regulates gene transcription and hematopoiesis, and its disruption by the leukemia-associated chromosomal translocations that affect genes for components of AML1 complex in view of deregulation of chromatin structure.

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Chromatin regulation by AML1 complex

Abstract

All Science Journal Classification (ASJC) codes

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