TY - JOUR
T1 - Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups
AU - Hirose, Yuichi
AU - Aldape, Kenneth
AU - Bollen, Andrew
AU - James, C. David
AU - Brat, Daniel
AU - Lamborn, Kathleen
AU - Berger, Mitchel
AU - Feuerstein, Burt G.
N1 - Funding Information:
Supported in part by the National Institutes of Health (NCI) grants CA13525, CA64898, and CA82103 ; Cancer Center core grant CA82103 ; and funds from the National Brain Tumor Foundation and the Farber Foundation.
PY - 2001
Y1 - 2001
N2 - Ependymoma occurs most frequently within the central nervous system of children and young adults. We determined relative chromosomal copy-number aberrations in 44 ependymomas using comparative genomic hybridization. The study included 24 intracranial and 20 spinal cord tumors from pediatric and adult patients. Frequent chromosomal aberrations in intracranial tumors were gain of 1q and losses on 6q, 9, and 13. Gain of 1q and loss on 9 were preferentially associated with histological grade 3 tumors. On the other hand, gain on chromosome 7 was recognized almost exclusively in spinal cord tumors, and was associated with various other chromosomal aberrations including frequent loss of 22q. We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.
AB - Ependymoma occurs most frequently within the central nervous system of children and young adults. We determined relative chromosomal copy-number aberrations in 44 ependymomas using comparative genomic hybridization. The study included 24 intracranial and 20 spinal cord tumors from pediatric and adult patients. Frequent chromosomal aberrations in intracranial tumors were gain of 1q and losses on 6q, 9, and 13. Gain of 1q and loss on 9 were preferentially associated with histological grade 3 tumors. On the other hand, gain on chromosome 7 was recognized almost exclusively in spinal cord tumors, and was associated with various other chromosomal aberrations including frequent loss of 22q. We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.
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U2 - 10.1016/S0002-9440(10)64061-8
DO - 10.1016/S0002-9440(10)64061-8
M3 - Article
C2 - 11238062
AN - SCOPUS:0035099106
SN - 0002-9440
VL - 158
SP - 1137
EP - 1143
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -