Chromosomal abnormalities subdivide neuroepithelial tumors into clinically relevant groups

Yuichi Hirose, Kazunari Yoshida

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Gliomas are the most common primary brain tumor, and are histopathologically classified according to their cell type and the degree of malignancy. However, sometimes diagnosis can be controversial, and tumors of the same entity possibly have a wide range of survival. Genetic analysis of these tumors is considered to have great importance in terms that it can provide clinically relevant classification of the tumors and compensate for the limitation of the histological classification. Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations (CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine. High grade (malignant) gliomas (i.e. anaplastic astrocytomas, anaplastic oligodendrogliomas and glioblastomas) have been reported to have a gain on 7p and losses on 9p and 10q. In case of ependymomas, frequent chromosomal aberrations in intracranial tumors were a gain on 1q and losses on 6q, and, on the other hand, a gain on chromosome 7 was recognized almost exclusively in spinal cord tumors. These data suggest that intracranial and spinal cord ependymomas are different genetic diseases and comprise different subgroups within one histological entity. In conclusion, genetic analysis of gliomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalKeio Journal of Medicine
Volume55
Issue number2
DOIs
Publication statusPublished - 19-07-2006

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Neuroepithelial Neoplasms
Chromosome Aberrations
Neoplasms
Glioma
Oligodendroglioma
Ependymoma
Astrocytoma
Spinal Cord Neoplasms
Procarbazine
Inborn Genetic Diseases
Chromosomes, Human, Pair 7
Comparative Genomic Hybridization
Vincristine
Glioblastoma
Brain Neoplasms
Spinal Cord
Survival

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Chromosomal abnormalities subdivide neuroepithelial tumors into clinically relevant groups",
abstract = "Gliomas are the most common primary brain tumor, and are histopathologically classified according to their cell type and the degree of malignancy. However, sometimes diagnosis can be controversial, and tumors of the same entity possibly have a wide range of survival. Genetic analysis of these tumors is considered to have great importance in terms that it can provide clinically relevant classification of the tumors and compensate for the limitation of the histological classification. Previous studies using comparative genomic hybridization (CGH) demonstrated that copy number aberrations (CNAs) were frequently recognized in these tumors, and revealed that a gain on chromosomal arm 7q was the most common CNA in diffuse astrocytomas, whereas a small population of the tumor showed losses on 1p/19q which characterizes oligodendrogliomas with good responsiveness to chemotherapeutic regime using procarbazine, nitrosourea and vincristine. High grade (malignant) gliomas (i.e. anaplastic astrocytomas, anaplastic oligodendrogliomas and glioblastomas) have been reported to have a gain on 7p and losses on 9p and 10q. In case of ependymomas, frequent chromosomal aberrations in intracranial tumors were a gain on 1q and losses on 6q, and, on the other hand, a gain on chromosome 7 was recognized almost exclusively in spinal cord tumors. These data suggest that intracranial and spinal cord ependymomas are different genetic diseases and comprise different subgroups within one histological entity. In conclusion, genetic analysis of gliomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed.",
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Chromosomal abnormalities subdivide neuroepithelial tumors into clinically relevant groups. / Hirose, Yuichi; Yoshida, Kazunari.

In: Keio Journal of Medicine, Vol. 55, No. 2, 19.07.2006, p. 52-58.

Research output: Contribution to journalReview article

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