TY - JOUR
T1 - Chromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats
AU - Murakumo, Yoshiki
AU - Takahashi, Masahide
AU - Arakawa, Atsushi
AU - Saito, Mitsuhiro
AU - Amo, Hiroyuki
AU - Katoh, Hideki
AU - Matsuyama, Mutsushi
PY - 1993/8
Y1 - 1993/8
N2 - The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.
AB - The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.
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U2 - 10.1111/j.1349-7006.1993.tb02054.x
DO - 10.1111/j.1349-7006.1993.tb02054.x
M3 - Article
C2 - 8407546
AN - SCOPUS:0027328078
SN - 0910-5050
VL - 84
SP - 838
EP - 840
JO - Japanese Journal of Cancer Research
JF - Japanese Journal of Cancer Research
IS - 8
ER -
