Chromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats

Yoshiki Murakumo; Masahide Takahashi; Atsushi Arakawa; Mitsuhiro Saito; Hiroyuki Amo; Hideki Katoh; Mutsushi Matsuyama

doi:10.1111/j.1349-7006.1993.tb02054.x

Chromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats

Yoshiki Murakumo
, Masahide Takahashi
, Atsushi Arakawa
, Mitsuhiro Saito
, Hiroyuki Amo
, Hideki Katoh
, Mutsushi Matsuyama

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.

Original language	English
Pages (from-to)	838-840
Number of pages	3
Journal	Japanese Journal of Cancer Research
Volume	84
Issue number	8
DOIs	https://doi.org/10.1111/j.1349-7006.1993.tb02054.x
Publication status	Published - 08-1993
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1111/j.1349-7006.1993.tb02054.x

Cite this

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title = "Chromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats",

abstract = "The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.",

keywords = "BUF/Mna rat, Chromosome 1, Large thymus, Ten‐1, Tsr‐1",

author = "Yoshiki Murakumo and Masahide Takahashi and Atsushi Arakawa and Mitsuhiro Saito and Hiroyuki Amo and Hideki Katoh and Mutsushi Matsuyama",

year = "1993",

month = aug,

doi = "10.1111/j.1349-7006.1993.tb02054.x",

language = "English",

volume = "84",

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journal = "Japanese Journal of Cancer Research",

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AU - Murakumo, Yoshiki

AU - Takahashi, Masahide

AU - Arakawa, Atsushi

AU - Saito, Mitsuhiro

AU - Amo, Hiroyuki

AU - Katoh, Hideki

AU - Matsuyama, Mutsushi

PY - 1993/8

Y1 - 1993/8

N2 - The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.

AB - The thymoma‐prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr‐1. At pre‐thymoma age, BUF/Mna rats have extremely large thyrauses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten‐1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten‐1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)Fl×BUF/Mna have led to the localization of Ten‐1 in chromosome 1. This result may provide an approach to clone Tsr‐1, which could be allelic to Ten‐1.

KW - BUF/Mna rat

KW - Chromosome 1

KW - Large thymus

KW - Ten‐1

KW - Tsr‐1

UR - https://www.scopus.com/pages/publications/0027328078

UR - https://www.scopus.com/pages/publications/0027328078#tab=citedBy

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DO - 10.1111/j.1349-7006.1993.tb02054.x

M3 - Article

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AN - SCOPUS:0027328078

SN - 0910-5050

VL - 84

SP - 838

EP - 840

JO - Japanese Journal of Cancer Research

JF - Japanese Journal of Cancer Research

IS - 8

ER -

Chromosomal Mapping of Genetic Locus Associated with Thymus‐size Enlargement in BUF/Mna Rats

Abstract

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All Science Journal Classification (ASJC) codes

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