Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

Kaichi Yoshizaki, Kayo Adachi, Seiko Kataoka, Atsushi Watanabe, Takeshi Tabira, Keikichi Takahashi, Hideaki Wakita

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Some lines of evidence have suggested that subcortical ischemic vascular dementia (SIVD) is a common form of vascular dementia (VaD), and that its pathological changes are the development of ischemic white matter (WM) lesions under chronic hypoperfusion and lacunes. Here, we have developed a novel mouse model of VaD with WM lesions, which was induced by right unilateral common carotid artery occlusion (rUCCAO). The mice subjected to rUCCAO exhibited chronic cerebral hypoperfusion in the cerebral hemisphere ipsilateral to rUCCAO monitored using a laser-Doppler flow meter (p < 0.01), and significant WM damage in the corpus callosum (p < 0.05) and deficits in object recognition test correlated with the damage of frontal-subcortical circuits (p < 0.01). However, no differences in spontaneous alternation or spontaneous motor activity were observed. Furthermore, the levels of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-6 (IL-6), significantly increased (p < 0.01), and those of anti-inflammatory cytokines, such as interleukin-4 (IL-4) and interleukin-10 (IL-10), significantly decreased in the ischemic brain (p < 0.05). These results suggest that this model is a useful tool for investigating the associations among inflammatory reactions, cognitive impairment, and WM damage, which may help elucidating the pathomechanism of VaD, particularly SIVD.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalExperimental Neurology
Volume210
Issue number2
DOIs
Publication statusPublished - 01-04-2008

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Vascular Dementia
Common Carotid Artery
Cytokines
Corpus Callosum
Cerebrum
Interleukin-1
Interleukin-4
Interleukin-10
Interleukin-6
Motor Activity
Lasers
Anti-Inflammatory Agents
Cognitive Dysfunction
White Matter
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Developmental Neuroscience

Cite this

Yoshizaki, Kaichi ; Adachi, Kayo ; Kataoka, Seiko ; Watanabe, Atsushi ; Tabira, Takeshi ; Takahashi, Keikichi ; Wakita, Hideaki. / Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. In: Experimental Neurology. 2008 ; Vol. 210, No. 2. pp. 585-591.
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Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. / Yoshizaki, Kaichi; Adachi, Kayo; Kataoka, Seiko; Watanabe, Atsushi; Tabira, Takeshi; Takahashi, Keikichi; Wakita, Hideaki.

In: Experimental Neurology, Vol. 210, No. 2, 01.04.2008, p. 585-591.

Research output: Contribution to journalArticle

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