Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Kuniaki Saito; Sanford P. Markey; Melvyn P. Heyes

doi:10.1016/0006-8993(91)91171-V

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Kuniaki Saito, Sanford P. Markey, Melvyn P. Heyes

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

Original language	English
Pages (from-to)	151-154
Number of pages	4
Journal	Brain Research
Volume	546
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91171-V
Publication status	Published - 12-04-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice",

abstract = "Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.",

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T1 - Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

AU - Saito, Kuniaki

AU - Markey, Sanford P.

AU - Heyes, Melvyn P.

PY - 1991/4/12

Y1 - 1991/4/12

N2 - Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

AB - Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of γ-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma l-kynurenine and QUIN levels. Mice chronically treated with γ-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

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Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Abstract

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