Chronic kidney disease and cardiovascular disease in a general Japanese population: The Hisayama Study

Toshiharu Ninomiya, Yutaka Kiyohara, Michiaki Kubo, Yumihiro Tanizaki, Yasufumi Doi, Ken Okubo, Yoshiyuki Wakugawa, Jun Hata, Yoshinori Oishi, Kentaro Shikata, Koji Yonemoto, Hideki Hirakata, Mitsuo Iida

Research output: Contribution to journalArticle

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Abstract

Background. Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations. Methods. To clarify this issue, we followed 2634 community-dwelling individuals without cardiovascular disease, aged 40 years or older, for 12 years and examined the relationship between chronic kidney disease and the incidence of cardiovascular disease. Results. During the follow-up period, 99 subjects (56 men and 43 women) experienced coronary heart disease, 137 subjects (60 men and 77 women) ischemic stroke, and 60 subjects (26 men and 34 women) hemorrhagic stroke. In men, the age-adjusted incidence of coronary heart disease was significantly higher in subjects with chronic kidney disease than in those without it (6.2 vs. 2.9 per 1000 person-years) (P < 0.05), but such a relationship was not observed with ischemic stroke. In contrast, in women, the age-adjusted incidence of ischemic stroke was significantly higher in subjects with chronic kidney disease than in those without it (3.4 vs. 2.5) (P < 0.05), while that of coronary heart disease was not. Chronic kidney disease was not found to be associated with the incidence of hemorrhagic stroke. In multivariate analysis, even after adjustments for traditional and nontraditional cardiovascular disease risk factors, chronic kidney disease was found to be an independent risk factor for the occurrence of coronary heart disease in men [hazard ratio (HR), 2.26; 95% CI, 1.06-4.79], and for the occurrence of ischemic stroke in women (HR, 1.91; 95% CI, 1.15-3.15). Conclusion. Our findings suggest that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.

Original languageEnglish
Pages (from-to)228-236
Number of pages9
JournalKidney International
Volume68
Issue number1
DOIs
Publication statusPublished - 01-07-2005
Externally publishedYes

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Chronic Renal Insufficiency
Cardiovascular Diseases
Stroke
Coronary Disease
Population
Incidence
Independent Living
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Ninomiya, Toshiharu ; Kiyohara, Yutaka ; Kubo, Michiaki ; Tanizaki, Yumihiro ; Doi, Yasufumi ; Okubo, Ken ; Wakugawa, Yoshiyuki ; Hata, Jun ; Oishi, Yoshinori ; Shikata, Kentaro ; Yonemoto, Koji ; Hirakata, Hideki ; Iida, Mitsuo. / Chronic kidney disease and cardiovascular disease in a general Japanese population : The Hisayama Study. In: Kidney International. 2005 ; Vol. 68, No. 1. pp. 228-236.
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abstract = "Background. Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations. Methods. To clarify this issue, we followed 2634 community-dwelling individuals without cardiovascular disease, aged 40 years or older, for 12 years and examined the relationship between chronic kidney disease and the incidence of cardiovascular disease. Results. During the follow-up period, 99 subjects (56 men and 43 women) experienced coronary heart disease, 137 subjects (60 men and 77 women) ischemic stroke, and 60 subjects (26 men and 34 women) hemorrhagic stroke. In men, the age-adjusted incidence of coronary heart disease was significantly higher in subjects with chronic kidney disease than in those without it (6.2 vs. 2.9 per 1000 person-years) (P < 0.05), but such a relationship was not observed with ischemic stroke. In contrast, in women, the age-adjusted incidence of ischemic stroke was significantly higher in subjects with chronic kidney disease than in those without it (3.4 vs. 2.5) (P < 0.05), while that of coronary heart disease was not. Chronic kidney disease was not found to be associated with the incidence of hemorrhagic stroke. In multivariate analysis, even after adjustments for traditional and nontraditional cardiovascular disease risk factors, chronic kidney disease was found to be an independent risk factor for the occurrence of coronary heart disease in men [hazard ratio (HR), 2.26; 95{\%} CI, 1.06-4.79], and for the occurrence of ischemic stroke in women (HR, 1.91; 95{\%} CI, 1.15-3.15). Conclusion. Our findings suggest that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.",
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Ninomiya, T, Kiyohara, Y, Kubo, M, Tanizaki, Y, Doi, Y, Okubo, K, Wakugawa, Y, Hata, J, Oishi, Y, Shikata, K, Yonemoto, K, Hirakata, H & Iida, M 2005, 'Chronic kidney disease and cardiovascular disease in a general Japanese population: The Hisayama Study', Kidney International, vol. 68, no. 1, pp. 228-236. https://doi.org/10.1111/j.1523-1755.2005.00397.x

Chronic kidney disease and cardiovascular disease in a general Japanese population : The Hisayama Study. / Ninomiya, Toshiharu; Kiyohara, Yutaka; Kubo, Michiaki; Tanizaki, Yumihiro; Doi, Yasufumi; Okubo, Ken; Wakugawa, Yoshiyuki; Hata, Jun; Oishi, Yoshinori; Shikata, Kentaro; Yonemoto, Koji; Hirakata, Hideki; Iida, Mitsuo.

In: Kidney International, Vol. 68, No. 1, 01.07.2005, p. 228-236.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chronic kidney disease and cardiovascular disease in a general Japanese population

T2 - The Hisayama Study

AU - Ninomiya, Toshiharu

AU - Kiyohara, Yutaka

AU - Kubo, Michiaki

AU - Tanizaki, Yumihiro

AU - Doi, Yasufumi

AU - Okubo, Ken

AU - Wakugawa, Yoshiyuki

AU - Hata, Jun

AU - Oishi, Yoshinori

AU - Shikata, Kentaro

AU - Yonemoto, Koji

AU - Hirakata, Hideki

AU - Iida, Mitsuo

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Background. Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations. Methods. To clarify this issue, we followed 2634 community-dwelling individuals without cardiovascular disease, aged 40 years or older, for 12 years and examined the relationship between chronic kidney disease and the incidence of cardiovascular disease. Results. During the follow-up period, 99 subjects (56 men and 43 women) experienced coronary heart disease, 137 subjects (60 men and 77 women) ischemic stroke, and 60 subjects (26 men and 34 women) hemorrhagic stroke. In men, the age-adjusted incidence of coronary heart disease was significantly higher in subjects with chronic kidney disease than in those without it (6.2 vs. 2.9 per 1000 person-years) (P < 0.05), but such a relationship was not observed with ischemic stroke. In contrast, in women, the age-adjusted incidence of ischemic stroke was significantly higher in subjects with chronic kidney disease than in those without it (3.4 vs. 2.5) (P < 0.05), while that of coronary heart disease was not. Chronic kidney disease was not found to be associated with the incidence of hemorrhagic stroke. In multivariate analysis, even after adjustments for traditional and nontraditional cardiovascular disease risk factors, chronic kidney disease was found to be an independent risk factor for the occurrence of coronary heart disease in men [hazard ratio (HR), 2.26; 95% CI, 1.06-4.79], and for the occurrence of ischemic stroke in women (HR, 1.91; 95% CI, 1.15-3.15). Conclusion. Our findings suggest that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.

AB - Background. Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations. Methods. To clarify this issue, we followed 2634 community-dwelling individuals without cardiovascular disease, aged 40 years or older, for 12 years and examined the relationship between chronic kidney disease and the incidence of cardiovascular disease. Results. During the follow-up period, 99 subjects (56 men and 43 women) experienced coronary heart disease, 137 subjects (60 men and 77 women) ischemic stroke, and 60 subjects (26 men and 34 women) hemorrhagic stroke. In men, the age-adjusted incidence of coronary heart disease was significantly higher in subjects with chronic kidney disease than in those without it (6.2 vs. 2.9 per 1000 person-years) (P < 0.05), but such a relationship was not observed with ischemic stroke. In contrast, in women, the age-adjusted incidence of ischemic stroke was significantly higher in subjects with chronic kidney disease than in those without it (3.4 vs. 2.5) (P < 0.05), while that of coronary heart disease was not. Chronic kidney disease was not found to be associated with the incidence of hemorrhagic stroke. In multivariate analysis, even after adjustments for traditional and nontraditional cardiovascular disease risk factors, chronic kidney disease was found to be an independent risk factor for the occurrence of coronary heart disease in men [hazard ratio (HR), 2.26; 95% CI, 1.06-4.79], and for the occurrence of ischemic stroke in women (HR, 1.91; 95% CI, 1.15-3.15). Conclusion. Our findings suggest that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.

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