Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review

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Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-stage kidney disease not only increase the risk of CAD, but they also modify its clinical presentation and cardinal symptoms. Management of CAD is complicated in CKD patients, due to their likelihood of comorbid conditions and potential for side effects during interventions. This summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD and CKD (including end-stage kidney disease and transplant recipients) seeks to improve understanding of the epidemiology, pathophysiology, diagnosis, and treatment of CAD in CKD and to identify knowledge gaps, areas of controversy, and priorities for research.

Original languageEnglish
Pages (from-to)1823-1838
Number of pages16
JournalJournal of the American College of Cardiology
Volume74
Issue number14
DOIs
Publication statusPublished - 08-10-2019

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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