Chronic kidney disease (CKD) and bone. Chronic kidney disease--mineral and bone disorder in predialysis patients

Daijo Inaguma, Miho Tatematsu

Research output: Contribution to journalReview article

Abstract

Chronic kidney disease-mineral and bone disorder (CKD-MBD) progressively develops from predialysis period. Phosphorus retention, hypocalcemia, and disturbance in activation of vitamin D lead to CKD-MBD. It is important to control the metabolic disorder, so that PTH level can be reduced. Recently, activated form of vitamin D plays important roles not only in calcium metabolism but in ontogenesis, cell differentiation, lipid metabolism and immunoregulation. Vitamin D replacement may be necessary because vitamin D is deficient in patients with predialysis CKD. However, there are possibilities that administration of vitamin D and/or calcium carbonate cause vascular calcification and decrease in residual renal function.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalClinical calcium
Volume19
Issue number4
Publication statusPublished - 04-2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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