Chronic myeloid leukemia following chemotherapy with 5′-deoxy-5-fluorouridine for gastric cancer

Motohiro Tsuzuki, Kousuke Handa, Kiyoko Yamamoto, Akio Hasegawa, Yukiya Yamamoto, Masato Watanabe, Syuichi Mizuta, Fumio Maruyama, Masataka Okamoto, Nobuhiko Emi, Kohji Ezaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5′-deoxy-5-fluorouridine (5′-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5′-DFUR as adjuvant chemotherapy for 6 years. He was placed on imatinib therapy, and achieved a major molecular response 10 months after the initiation of therapy. This is the first reported case of therapy-related CML following 5′-DFUR treatment.

Original languageEnglish
Pages (from-to)1739-1741
Number of pages3
JournalInternal Medicine
Volume47
Issue number19
DOIs
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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