Chronic phencyclidine increases methionine-enkephalin level in mouse striatum

Toshitaka Nabeshima, Masayuki Hiramatsu, Manabu Amano, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The chronic administration of phencyclidine-HCl (PCP-HCl), 10 mg/kg, for 6-7 days resulted in a significant increase in the striatal methionine-enkephalin level, although acute administration induced no change of methionine-enkephalin level in this area. The methionine-enkephalin levels in other areas investigated, i.e. the medulla oblongata/pons, the midbrain, the hypothalamus and the cortex, were unchanged after chronic PCP treatment. These results suggest that chronic administration of PCP alters the enkephalinergic neuronal activity in the striatum.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 27-05-1983
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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