Cigarette smoking and mortality due to stomach cancer: Findings from the JACC study

Yoshihisa Fujino, Tetsuya Mizoue, Noritaka Tokui, Shogo Kikuchi, Yoshihiro Hoshiyama, Hideaki Toyoshima, Hiroshi Yatsuya, Kiyomi Sakata, Akiko Tamakoshi, Reiko Ide, Tatsuhiko Kubo, Takesumi Yoshimura, Mitsuru Mori, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Yutaka Inaba, Yoshiharu HoshiyamaHiroshi Suzuki, Hiroyuki Shimizu, Kenji Wakai, Shinkan Tokudome, Yoshinori Ito, Shuji Hashimoto, Akio Koizumi, Takashi Kawamura, Yoshiyuki Watanabe, Tsuneharu Miki, Chigusa Date, Takayuki Nose, Norihiko Hayakawa, Akira Shibata, Naoyuki Okamoto, Hideo Shio, Yoshiyuki Ohno, Tomoyuki Kitagawa, Toshio Kuroki, Kazuo Tajima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Several epidermiologic studies reported the positive association between cigarette smoking and stomach cancer. The prevalence of smoking in men remains high in Japan compared to other developed countries. It is therefore of great importance to determine the impact of cigarette smoking on stomach cancer among the Japanese population. The Japan Collaborative Cohort Study (JACC Study) provided an opportunity to examine the association between smoking and the risk of mortality due to stomach cancer. Method: A baseline survey was conducted throughout Japan from 1988 through 1990 among 110,792 inhabitants of 45 areas. Data retrieved for 98,062 participants (43,482 male and 54,580 female) who provided sufficient information about their smoking habits, without any history of caner at the baseline. Of total 970,251 person-years, 757deaths due to stomach caner were identified. Results: Current smokers were at a higher risk of death due to stomach cancer than non-smokers (Hazard ratio = 1.36; 95% confidence interval [Cl]: 1.07, 1.73). The risk of, stomach cancer for men who smoked 15 or more cigarettes per day was approximately 1.4-fold greater than that of non-smokers, and those who smoked 35 or more cigarettes per day had an approximately 1.7-fold higher risk of stomach cancer, although the dose-response trend among men was unclear (p for trend = 0.063). No associations between smoking and stomach cancer were detected among women. Conclusion: The present results, together with previous findings, strongly support a hypothesis that cigarette smoking increases the risk of stomach cancer in Japanese men.

Original languageEnglish
Pages (from-to)S113-S119
JournalJournal of epidemiology
Volume15
Issue numberSUPPL. 2
DOIs
Publication statusPublished - 14-10-2005

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Stomach Neoplasms
Smoking
Mortality
Japan
Tobacco Products
Developed Countries
Habits
Stomach
Cohort Studies
Confidence Intervals
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Fujino, Y., Mizoue, T., Tokui, N., Kikuchi, S., Hoshiyama, Y., Toyoshima, H., ... Tajima, K. (2005). Cigarette smoking and mortality due to stomach cancer: Findings from the JACC study. Journal of epidemiology, 15(SUPPL. 2), S113-S119. https://doi.org/10.2188/jea.15.S113
Fujino, Yoshihisa ; Mizoue, Tetsuya ; Tokui, Noritaka ; Kikuchi, Shogo ; Hoshiyama, Yoshihiro ; Toyoshima, Hideaki ; Yatsuya, Hiroshi ; Sakata, Kiyomi ; Tamakoshi, Akiko ; Ide, Reiko ; Kubo, Tatsuhiko ; Yoshimura, Takesumi ; Mori, Mitsuru ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Inaba, Yutaka ; Hoshiyama, Yoshiharu ; Suzuki, Hiroshi ; Shimizu, Hiroyuki ; Wakai, Kenji ; Tokudome, Shinkan ; Ito, Yoshinori ; Hashimoto, Shuji ; Koizumi, Akio ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Miki, Tsuneharu ; Date, Chigusa ; Nose, Takayuki ; Hayakawa, Norihiko ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo ; Ohno, Yoshiyuki ; Kitagawa, Tomoyuki ; Kuroki, Toshio ; Tajima, Kazuo. / Cigarette smoking and mortality due to stomach cancer : Findings from the JACC study. In: Journal of epidemiology. 2005 ; Vol. 15, No. SUPPL. 2. pp. S113-S119.
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abstract = "Background: Several epidermiologic studies reported the positive association between cigarette smoking and stomach cancer. The prevalence of smoking in men remains high in Japan compared to other developed countries. It is therefore of great importance to determine the impact of cigarette smoking on stomach cancer among the Japanese population. The Japan Collaborative Cohort Study (JACC Study) provided an opportunity to examine the association between smoking and the risk of mortality due to stomach cancer. Method: A baseline survey was conducted throughout Japan from 1988 through 1990 among 110,792 inhabitants of 45 areas. Data retrieved for 98,062 participants (43,482 male and 54,580 female) who provided sufficient information about their smoking habits, without any history of caner at the baseline. Of total 970,251 person-years, 757deaths due to stomach caner were identified. Results: Current smokers were at a higher risk of death due to stomach cancer than non-smokers (Hazard ratio = 1.36; 95{\%} confidence interval [Cl]: 1.07, 1.73). The risk of, stomach cancer for men who smoked 15 or more cigarettes per day was approximately 1.4-fold greater than that of non-smokers, and those who smoked 35 or more cigarettes per day had an approximately 1.7-fold higher risk of stomach cancer, although the dose-response trend among men was unclear (p for trend = 0.063). No associations between smoking and stomach cancer were detected among women. Conclusion: The present results, together with previous findings, strongly support a hypothesis that cigarette smoking increases the risk of stomach cancer in Japanese men.",
author = "Yoshihisa Fujino and Tetsuya Mizoue and Noritaka Tokui and Shogo Kikuchi and Yoshihiro Hoshiyama and Hideaki Toyoshima and Hiroshi Yatsuya and Kiyomi Sakata and Akiko Tamakoshi and Reiko Ide and Tatsuhiko Kubo and Takesumi Yoshimura and Mitsuru Mori and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Yutaka Inaba and Yoshiharu Hoshiyama and Hiroshi Suzuki and Hiroyuki Shimizu and Kenji Wakai and Shinkan Tokudome and Yoshinori Ito and Shuji Hashimoto and Akio Koizumi and Takashi Kawamura and Yoshiyuki Watanabe and Tsuneharu Miki and Chigusa Date and Takayuki Nose and Norihiko Hayakawa and Akira Shibata and Naoyuki Okamoto and Hideo Shio and Yoshiyuki Ohno and Tomoyuki Kitagawa and Toshio Kuroki and Kazuo Tajima",
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Fujino, Y, Mizoue, T, Tokui, N, Kikuchi, S, Hoshiyama, Y, Toyoshima, H, Yatsuya, H, Sakata, K, Tamakoshi, A, Ide, R, Kubo, T, Yoshimura, T, Mori, M, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Inaba, Y, Hoshiyama, Y, Suzuki, H, Shimizu, H, Wakai, K, Tokudome, S, Ito, Y, Hashimoto, S, Koizumi, A, Kawamura, T, Watanabe, Y, Miki, T, Date, C, Nose, T, Hayakawa, N, Shibata, A, Okamoto, N, Shio, H, Ohno, Y, Kitagawa, T, Kuroki, T & Tajima, K 2005, 'Cigarette smoking and mortality due to stomach cancer: Findings from the JACC study', Journal of epidemiology, vol. 15, no. SUPPL. 2, pp. S113-S119. https://doi.org/10.2188/jea.15.S113

Cigarette smoking and mortality due to stomach cancer : Findings from the JACC study. / Fujino, Yoshihisa; Mizoue, Tetsuya; Tokui, Noritaka; Kikuchi, Shogo; Hoshiyama, Yoshihiro; Toyoshima, Hideaki; Yatsuya, Hiroshi; Sakata, Kiyomi; Tamakoshi, Akiko; Ide, Reiko; Kubo, Tatsuhiko; Yoshimura, Takesumi; Mori, Mitsuru; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Inaba, Yutaka; Hoshiyama, Yoshiharu; Suzuki, Hiroshi; Shimizu, Hiroyuki; Wakai, Kenji; Tokudome, Shinkan; Ito, Yoshinori; Hashimoto, Shuji; Koizumi, Akio; Kawamura, Takashi; Watanabe, Yoshiyuki; Miki, Tsuneharu; Date, Chigusa; Nose, Takayuki; Hayakawa, Norihiko; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo; Ohno, Yoshiyuki; Kitagawa, Tomoyuki; Kuroki, Toshio; Tajima, Kazuo.

In: Journal of epidemiology, Vol. 15, No. SUPPL. 2, 14.10.2005, p. S113-S119.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cigarette smoking and mortality due to stomach cancer

T2 - Findings from the JACC study

AU - Fujino, Yoshihisa

AU - Mizoue, Tetsuya

AU - Tokui, Noritaka

AU - Kikuchi, Shogo

AU - Hoshiyama, Yoshihiro

AU - Toyoshima, Hideaki

AU - Yatsuya, Hiroshi

AU - Sakata, Kiyomi

AU - Tamakoshi, Akiko

AU - Ide, Reiko

AU - Kubo, Tatsuhiko

AU - Yoshimura, Takesumi

AU - Mori, Mitsuru

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Inaba, Yutaka

AU - Hoshiyama, Yoshiharu

AU - Suzuki, Hiroshi

AU - Shimizu, Hiroyuki

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Ito, Yoshinori

AU - Hashimoto, Shuji

AU - Koizumi, Akio

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Nose, Takayuki

AU - Hayakawa, Norihiko

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

AU - Ohno, Yoshiyuki

AU - Kitagawa, Tomoyuki

AU - Kuroki, Toshio

AU - Tajima, Kazuo

PY - 2005/10/14

Y1 - 2005/10/14

N2 - Background: Several epidermiologic studies reported the positive association between cigarette smoking and stomach cancer. The prevalence of smoking in men remains high in Japan compared to other developed countries. It is therefore of great importance to determine the impact of cigarette smoking on stomach cancer among the Japanese population. The Japan Collaborative Cohort Study (JACC Study) provided an opportunity to examine the association between smoking and the risk of mortality due to stomach cancer. Method: A baseline survey was conducted throughout Japan from 1988 through 1990 among 110,792 inhabitants of 45 areas. Data retrieved for 98,062 participants (43,482 male and 54,580 female) who provided sufficient information about their smoking habits, without any history of caner at the baseline. Of total 970,251 person-years, 757deaths due to stomach caner were identified. Results: Current smokers were at a higher risk of death due to stomach cancer than non-smokers (Hazard ratio = 1.36; 95% confidence interval [Cl]: 1.07, 1.73). The risk of, stomach cancer for men who smoked 15 or more cigarettes per day was approximately 1.4-fold greater than that of non-smokers, and those who smoked 35 or more cigarettes per day had an approximately 1.7-fold higher risk of stomach cancer, although the dose-response trend among men was unclear (p for trend = 0.063). No associations between smoking and stomach cancer were detected among women. Conclusion: The present results, together with previous findings, strongly support a hypothesis that cigarette smoking increases the risk of stomach cancer in Japanese men.

AB - Background: Several epidermiologic studies reported the positive association between cigarette smoking and stomach cancer. The prevalence of smoking in men remains high in Japan compared to other developed countries. It is therefore of great importance to determine the impact of cigarette smoking on stomach cancer among the Japanese population. The Japan Collaborative Cohort Study (JACC Study) provided an opportunity to examine the association between smoking and the risk of mortality due to stomach cancer. Method: A baseline survey was conducted throughout Japan from 1988 through 1990 among 110,792 inhabitants of 45 areas. Data retrieved for 98,062 participants (43,482 male and 54,580 female) who provided sufficient information about their smoking habits, without any history of caner at the baseline. Of total 970,251 person-years, 757deaths due to stomach caner were identified. Results: Current smokers were at a higher risk of death due to stomach cancer than non-smokers (Hazard ratio = 1.36; 95% confidence interval [Cl]: 1.07, 1.73). The risk of, stomach cancer for men who smoked 15 or more cigarettes per day was approximately 1.4-fold greater than that of non-smokers, and those who smoked 35 or more cigarettes per day had an approximately 1.7-fold higher risk of stomach cancer, although the dose-response trend among men was unclear (p for trend = 0.063). No associations between smoking and stomach cancer were detected among women. Conclusion: The present results, together with previous findings, strongly support a hypothesis that cigarette smoking increases the risk of stomach cancer in Japanese men.

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Fujino Y, Mizoue T, Tokui N, Kikuchi S, Hoshiyama Y, Toyoshima H et al. Cigarette smoking and mortality due to stomach cancer: Findings from the JACC study. Journal of epidemiology. 2005 Oct 14;15(SUPPL. 2):S113-S119. https://doi.org/10.2188/jea.15.S113