Cigarette smoking and other risk factors for kidney cancer death in a Japanese population: Japan collaborative cohort study for evaluation of cancer risk (JACC study)

Masakazu Washio, Mitsuru Mori, Kazuya Mikami, Tsuneharu Miki, Yoshiyuki Watanabe, Masahiro Nakao, Tatsuhiko Kubo, Koji Suzuki, Kotaro Ozasa, Kenji Wakai, Akiko Tamakoshi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Cigarette smoking is the largest single recognized cause of human cancers. In Western countries, many epidemiologists have reported risk factors for kidney cancer including smoking. However, little is known about the Japanese population. Materials and Methods: We evaluated the association of smoking with the risk of kidney cancer death in the Japan Collaborative Cohort (JACC) Study. Participants included 46,395 males and 64,190 females. The Cox proportional hazards model was used to determine age-and-sex adjusted relative risks. Results: A total of 62 males and 26 females died from kidney cancer during the follow-up of 707,136 and 1,025,703 person-years, respectively. Heavy smokers (Brinkman index >1200), fondness of fatty foods, hypertension, diabetes mellitus (DM), and obesity were suggested to increase the risk of renal cell carcinoma while walking was suggested to decrease the risk. Even after controlling for age, sex, alcohol drinking and DM, heavy smoking significantly increased the risk. Conclusions: The present study suggests that six factors including smoking may increase and/or reduce the risk of kidney cancer in the Japanese population. Because of the small number of outcomes, however, we did not evaluate these factors after adjusting for all possible confounding factors. Further studies may be needed to confirm the findings in this study.

Original languageEnglish
Pages (from-to)6523-6528
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume14
Issue number11
DOIs
Publication statusPublished - 01-01-2013

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Kidney Neoplasms
Japan
Cohort Studies
Smoking
Population
Neoplasms
Diabetes Mellitus
Renal Cell Carcinoma
Proportional Hazards Models
Alcohol Drinking
Walking
Obesity
Hypertension
Food

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Washio, Masakazu ; Mori, Mitsuru ; Mikami, Kazuya ; Miki, Tsuneharu ; Watanabe, Yoshiyuki ; Nakao, Masahiro ; Kubo, Tatsuhiko ; Suzuki, Koji ; Ozasa, Kotaro ; Wakai, Kenji ; Tamakoshi, Akiko. / Cigarette smoking and other risk factors for kidney cancer death in a Japanese population : Japan collaborative cohort study for evaluation of cancer risk (JACC study). In: Asian Pacific Journal of Cancer Prevention. 2013 ; Vol. 14, No. 11. pp. 6523-6528.
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Cigarette smoking and other risk factors for kidney cancer death in a Japanese population : Japan collaborative cohort study for evaluation of cancer risk (JACC study). / Washio, Masakazu; Mori, Mitsuru; Mikami, Kazuya; Miki, Tsuneharu; Watanabe, Yoshiyuki; Nakao, Masahiro; Kubo, Tatsuhiko; Suzuki, Koji; Ozasa, Kotaro; Wakai, Kenji; Tamakoshi, Akiko.

In: Asian Pacific Journal of Cancer Prevention, Vol. 14, No. 11, 01.01.2013, p. 6523-6528.

Research output: Contribution to journalArticle

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T1 - Cigarette smoking and other risk factors for kidney cancer death in a Japanese population

T2 - Japan collaborative cohort study for evaluation of cancer risk (JACC study)

AU - Washio, Masakazu

AU - Mori, Mitsuru

AU - Mikami, Kazuya

AU - Miki, Tsuneharu

AU - Watanabe, Yoshiyuki

AU - Nakao, Masahiro

AU - Kubo, Tatsuhiko

AU - Suzuki, Koji

AU - Ozasa, Kotaro

AU - Wakai, Kenji

AU - Tamakoshi, Akiko

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: Cigarette smoking is the largest single recognized cause of human cancers. In Western countries, many epidemiologists have reported risk factors for kidney cancer including smoking. However, little is known about the Japanese population. Materials and Methods: We evaluated the association of smoking with the risk of kidney cancer death in the Japan Collaborative Cohort (JACC) Study. Participants included 46,395 males and 64,190 females. The Cox proportional hazards model was used to determine age-and-sex adjusted relative risks. Results: A total of 62 males and 26 females died from kidney cancer during the follow-up of 707,136 and 1,025,703 person-years, respectively. Heavy smokers (Brinkman index >1200), fondness of fatty foods, hypertension, diabetes mellitus (DM), and obesity were suggested to increase the risk of renal cell carcinoma while walking was suggested to decrease the risk. Even after controlling for age, sex, alcohol drinking and DM, heavy smoking significantly increased the risk. Conclusions: The present study suggests that six factors including smoking may increase and/or reduce the risk of kidney cancer in the Japanese population. Because of the small number of outcomes, however, we did not evaluate these factors after adjusting for all possible confounding factors. Further studies may be needed to confirm the findings in this study.

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