Cigarette smoking and serum soluble Fas levels: Findings from the JACC study

Akiko Tamakoshi, Koji Suzuki, Yingsong Lin, Yoshinori Ito, Kiyoko Yagyu, Shogo Kikuchi, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Kei Nakachi

Research output: Contribution to journalArticle

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Abstract

Cigarette smoking enhances low-grade systemic inflammation in the lung and other organs. Activated immune cells play an important role at early and late stages of inflammation, and in recent years, soluble Fas (sFas), an isoform of death molecule Fas, was found to interfere with the apoptotic pathways of these activated immune cells. The aim of this study was to confirm the association between cigarette smoking and sFas levels in healthy male subjects. We measured serum sFas levels of 4415 male subjects selected as controls for a nested case-control study within the large-scale cohort study conducted in Japan, called the JACC Study. Smoking status at baseline was evaluated by a self-administered questionnaire. Least square means of sFas according to smoking status and numbers of cigarettes smoked per day among smokers were calculated and adjusted for possible confounding factors. Mean sFas levels showed an increasing trend across never smokers, past smokers and current smokers, as 2.21 (95% CI: 2.14-2.27) ng/ml, 2.29 (2.22-2.36) ng/ml, and 2.36 (2.30-2.43) ng/ml, respectively. However, no dose-response relationship was observed between the number of cigarettes smoked per day and sFas levels among smokers.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume679
Issue number1-2
DOIs
Publication statusPublished - 01-09-2009

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Smoking
Serum
Tobacco Products
Least-Squares Analysis
Case-Control Studies
Pneumonia
Healthy Volunteers
Japan
Protein Isoforms
Cohort Studies
Inflammation

All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

Tamakoshi, Akiko ; Suzuki, Koji ; Lin, Yingsong ; Ito, Yoshinori ; Yagyu, Kiyoko ; Kikuchi, Shogo ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Nakachi, Kei. / Cigarette smoking and serum soluble Fas levels : Findings from the JACC study. In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2009 ; Vol. 679, No. 1-2. pp. 79-83.
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Tamakoshi, A, Suzuki, K, Lin, Y, Ito, Y, Yagyu, K, Kikuchi, S, Watanabe, Y, Inaba, Y, Tajima, K & Nakachi, K 2009, 'Cigarette smoking and serum soluble Fas levels: Findings from the JACC study', Mutation Research - Genetic Toxicology and Environmental Mutagenesis, vol. 679, no. 1-2, pp. 79-83. https://doi.org/10.1016/j.mrgentox.2009.08.002

Cigarette smoking and serum soluble Fas levels : Findings from the JACC study. / Tamakoshi, Akiko; Suzuki, Koji; Lin, Yingsong; Ito, Yoshinori; Yagyu, Kiyoko; Kikuchi, Shogo; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Nakachi, Kei.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 679, No. 1-2, 01.09.2009, p. 79-83.

Research output: Contribution to journalArticle

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AU - Tamakoshi, Akiko

AU - Suzuki, Koji

AU - Lin, Yingsong

AU - Ito, Yoshinori

AU - Yagyu, Kiyoko

AU - Kikuchi, Shogo

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Nakachi, Kei

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N2 - Cigarette smoking enhances low-grade systemic inflammation in the lung and other organs. Activated immune cells play an important role at early and late stages of inflammation, and in recent years, soluble Fas (sFas), an isoform of death molecule Fas, was found to interfere with the apoptotic pathways of these activated immune cells. The aim of this study was to confirm the association between cigarette smoking and sFas levels in healthy male subjects. We measured serum sFas levels of 4415 male subjects selected as controls for a nested case-control study within the large-scale cohort study conducted in Japan, called the JACC Study. Smoking status at baseline was evaluated by a self-administered questionnaire. Least square means of sFas according to smoking status and numbers of cigarettes smoked per day among smokers were calculated and adjusted for possible confounding factors. Mean sFas levels showed an increasing trend across never smokers, past smokers and current smokers, as 2.21 (95% CI: 2.14-2.27) ng/ml, 2.29 (2.22-2.36) ng/ml, and 2.36 (2.30-2.43) ng/ml, respectively. However, no dose-response relationship was observed between the number of cigarettes smoked per day and sFas levels among smokers.

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