Cigarette smoking and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort Study

Yoshimitsu Niwa, Kenji Wakai, Sadao Suzuki, Koji Tamakoshi, Yingsong Lin, Hiroshi Yatsuya, Takaaki Kondo, Kazuko Nishio, Akio Yamamoto, Shinkan Tokudome, Nobuyuki Hamajima, Hideaki Toyoshima, Akiko Tamakoshi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. Methods: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. Results: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] × number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). Conclusions: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalJournal of Obstetrics and Gynaecology Research
Volume31
Issue number2
DOIs
Publication statusPublished - 01-04-2005

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Ovarian Neoplasms
Cohort Studies
Smoking
Confidence Intervals
Population
Proportional Hazards Models
Tobacco Products
Habits
Neoplasms
Japan

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Niwa, Yoshimitsu ; Wakai, Kenji ; Suzuki, Sadao ; Tamakoshi, Koji ; Lin, Yingsong ; Yatsuya, Hiroshi ; Kondo, Takaaki ; Nishio, Kazuko ; Yamamoto, Akio ; Tokudome, Shinkan ; Hamajima, Nobuyuki ; Toyoshima, Hideaki ; Tamakoshi, Akiko. / Cigarette smoking and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort Study. In: Journal of Obstetrics and Gynaecology Research. 2005 ; Vol. 31, No. 2. pp. 144-151.
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abstract = "Aim: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. Methods: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. Results: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95{\%} confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95{\%} CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95{\%} CI = 0.20-10.92), 5.56 (95{\%} CI = 1.68-19.06), and 1.86 (95{\%} CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] × number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). Conclusions: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.",
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Niwa, Y, Wakai, K, Suzuki, S, Tamakoshi, K, Lin, Y, Yatsuya, H, Kondo, T, Nishio, K, Yamamoto, A, Tokudome, S, Hamajima, N, Toyoshima, H & Tamakoshi, A 2005, 'Cigarette smoking and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort Study', Journal of Obstetrics and Gynaecology Research, vol. 31, no. 2, pp. 144-151. https://doi.org/10.1111/j.1447-0756.2005.00261.x

Cigarette smoking and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort Study. / Niwa, Yoshimitsu; Wakai, Kenji; Suzuki, Sadao; Tamakoshi, Koji; Lin, Yingsong; Yatsuya, Hiroshi; Kondo, Takaaki; Nishio, Kazuko; Yamamoto, Akio; Tokudome, Shinkan; Hamajima, Nobuyuki; Toyoshima, Hideaki; Tamakoshi, Akiko.

In: Journal of Obstetrics and Gynaecology Research, Vol. 31, No. 2, 01.04.2005, p. 144-151.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cigarette smoking and the risk of ovarian cancer in the Japanese population

T2 - Findings from the Japanese Collaborate Cohort Study

AU - Niwa, Yoshimitsu

AU - Wakai, Kenji

AU - Suzuki, Sadao

AU - Tamakoshi, Koji

AU - Lin, Yingsong

AU - Yatsuya, Hiroshi

AU - Kondo, Takaaki

AU - Nishio, Kazuko

AU - Yamamoto, Akio

AU - Tokudome, Shinkan

AU - Hamajima, Nobuyuki

AU - Toyoshima, Hideaki

AU - Tamakoshi, Akiko

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Aim: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. Methods: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. Results: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] × number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). Conclusions: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

AB - Aim: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. Methods: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. Results: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] × number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). Conclusions: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

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