Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart

Maoqing Tong, Eiichi Watanabe, Naoki Yamamoto, Misao Nagahata-Ishiguro, Koji Maemura, Norihiko Takeda, Ryozo Nagai, Yukio Ozaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Significant circadian variations exist in the frequency of cardiac arrhythmia, but few studies have examined the relation between cardiac ion channels genes and biological clocks. We investigated this relation using suprachiasmatic nuclei lesion (SCNX) and pharmacological autonomic nervous system block (ANSB) mice. Significant 24-h variations were observed in the expression of clock genes Per2, Bmal1, and Dbp and ion channel genes KCNA5, KCND2, KCHIP2, and KCNK3 in the control mice hearts. In the SCNX mice, all genes examined lost circadian rhythm. In the ANSB mice, the expressions of the three clock genes were dampened significantly but still had circadian rhythm, whereas the four ion channel gene expressions lost rhythm. Heart rate also lost circadian rhythm in both the SCNX and ANSB mice. These results suggest that some ion channel gene expressions might be regulated by the central clock in the SCN through the ANS but not the peripheral clock in the heart.

Original languageEnglish
Pages (from-to)519-530
Number of pages12
JournalBiological Rhythm Research
Volume44
Issue number4
DOIs
Publication statusPublished - 01-08-2013

Fingerprint

ion channels
Ion Channels
autonomic nervous system
circadian rhythm
heart
Autonomic Nervous System
nervous system
Circadian Rhythm
ion
gene
mice
Genes
Gene Expression
genes
gene expression
Biological Clocks
biological clocks
Suprachiasmatic Nucleus
arrhythmia
lesion

All Science Journal Classification (ASJC) codes

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Physiology (medical)

Cite this

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abstract = "Significant circadian variations exist in the frequency of cardiac arrhythmia, but few studies have examined the relation between cardiac ion channels genes and biological clocks. We investigated this relation using suprachiasmatic nuclei lesion (SCNX) and pharmacological autonomic nervous system block (ANSB) mice. Significant 24-h variations were observed in the expression of clock genes Per2, Bmal1, and Dbp and ion channel genes KCNA5, KCND2, KCHIP2, and KCNK3 in the control mice hearts. In the SCNX mice, all genes examined lost circadian rhythm. In the ANSB mice, the expressions of the three clock genes were dampened significantly but still had circadian rhythm, whereas the four ion channel gene expressions lost rhythm. Heart rate also lost circadian rhythm in both the SCNX and ANSB mice. These results suggest that some ion channel gene expressions might be regulated by the central clock in the SCN through the ANS but not the peripheral clock in the heart.",
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Circadian expressions of cardiac ion channel genes in mouse might be associated with the central clock in the SCN but not the peripheral clock in the heart. / Tong, Maoqing; Watanabe, Eiichi; Yamamoto, Naoki; Nagahata-Ishiguro, Misao; Maemura, Koji; Takeda, Norihiko; Nagai, Ryozo; Ozaki, Yukio.

In: Biological Rhythm Research, Vol. 44, No. 4, 01.08.2013, p. 519-530.

Research output: Contribution to journalArticle

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AU - Tong, Maoqing

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