TY - JOUR
T1 - Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model
AU - Hagihara, Hideo
AU - Horikawa, Tomoyasu
AU - Nakamura, Hironori K.
AU - Umemori, Juzoh
AU - Shoji, Hirotaka
AU - Kamitani, Yukiyasu
AU - Miyakawa, Tsuyoshi
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain.
AB - Bipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain.
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U2 - 10.1016/j.celrep.2016.02.067
DO - 10.1016/j.celrep.2016.02.067
M3 - Article
C2 - 27028761
AN - SCOPUS:84963894596
SN - 2211-1247
VL - 14
SP - 2784
EP - 2796
JO - Cell Reports
JF - Cell Reports
IS - 12
ER -