Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction

Tousei Hashimoto, Junnichi Ishii, Fumihiko Kitagawa, Shingo Yamada, Kousuke Hattori, Masanori Okumura, Hiroyuki Naruse, Sadako Motoyama, Shigeru Matsui, Ikuko Tanaka, Hideo Izawa, Ikuro Maruyama, Masanori Nomura, Yukio Ozaki

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33 Citations (Scopus)

Abstract

Objective: High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern molecule, which suggests a potential role of this protein in the pathophysiology of acute coronary syndrome (ACS). Circulating HMGB1 has been shown to be independently associated with cardiac mortality in ST-segment elevation myocardial infarction. However, its prognostic value remains unclear in unstable angina and non-ST-segment elevation myocardial infarction (UA/NSTEMI). Methods: HMGB1, high-sensitivity C-reactive protein (hsCRP), cardiac troponin I and B-type natriuretic peptide concentrations were measured on admission in 258 consecutive patients (mean age of 67 years) hospitalized for UA/NSTEMI within 24. h (mean, 7.4. h) of the onset of chest symptoms. Results: A total of 38 (14.7%) cardiovascular deaths, including 10 in-hospital deaths, occurred during a median follow-up period of 49 months after admission. In a stepwise Cox regression analysis including 19 well-known clinical predictors of ACS, HMGB1 [relative risk (RR) 3.24 per 10-fold increment; P=. 0.0003], cardiac troponin I (RR 1.83 per 10-fold increment, P=. 0.0007), Killip class. >. 1 (RR 4.67, P=. 0.0001) and age (RR 1.05 per 1-year increment, P=. 0.03), but not hsCRP, were independently associated with cardiovascular mortality. In-hospital and cardiovascular mortality rates were higher in patients with increased HMGB1 (≥2.4. ng/mL of median value) than those without increased HMGB1 (6.3% vs. 1.5%, P=. 0.04; and 23% vs. 6.9%, P=. 0.0003). Conclusion: Circulating concentration of HMGB1 on admission may be a potential and independent predictor of cardiovascular mortality in patients hospitalized for UA/NSTEMI within 24. h of onset.

Original languageEnglish
Pages (from-to)490-495
Number of pages6
JournalAtherosclerosis
Volume221
Issue number2
DOIs
Publication statusPublished - 01-04-2012

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Hashimoto, T., Ishii, J., Kitagawa, F., Yamada, S., Hattori, K., Okumura, M., Naruse, H., Motoyama, S., Matsui, S., Tanaka, I., Izawa, H., Maruyama, I., Nomura, M., & Ozaki, Y. (2012). Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction. Atherosclerosis, 221(2), 490-495. https://doi.org/10.1016/j.atherosclerosis.2012.01.040