Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.

Koichi Takeda, Hirotoshi Utsunomiya, Seiji Kakiuchi, Yoshiharu Okuno, Koji Oda, Ken ichi Inada, Yutaka Tsutsumi, Takuji Tanaka, Kennichi Kakudo

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23 Citations (Scopus)

Abstract

We examined the efficacy of auraptene (AUR), an antioxidant agent of a citrus coumarin derivative, for suppressing gastric inflammation introduced by Helicobacter pylori (Hp) infection in Mongolian gerbils (MGs). Hp-infected MGs were placed on diets containing 100 or 500 ppm AUR for 7 weeks. Real-time PCR was used to estimate the Hp population in glandular stomach lesions, and a histological assessment of inflammation was performed. At a dose of 500 ppm, AUR reduced the Hp population to 21.9+/-12.0% of the control group (p<0.05). However, no apparent differences were seen in hematoxylin and eosin sections between AUR-administered and control groups. We conclude that dietary supplementation with 500 ppm of AUR suppresses Hp colonization, but does not reduce gastric inflammation.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalJournal of oleo science
Volume56
Issue number5
DOIs
Publication statusPublished - 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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    Takeda, K., Utsunomiya, H., Kakiuchi, S., Okuno, Y., Oda, K., Inada, K. I., Tsutsumi, Y., Tanaka, T., & Kakudo, K. (2007). Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils. Journal of oleo science, 56(5), 253-260. https://doi.org/10.5650/jos.56.253