Classification of HHV-6A and HHV-6B as distinct viruses

Dharam Ablashi, Henri Agut, Roberto Alvarez-Lafuente, Duncan A. Clark, Stephen Dewhurst, Dario DiLuca, Louis Flamand, Niza Frenkel, Robert Gallo, Ursula A. Gompels, Per Höllsberg, Steven Jacobson, Mario Luppi, Paolo Lusso, Mauro Malnati, Peter Medveczky, Yasuko Mori, Philip E. Pellett, Joshua C. Pritchett, Koichi Yamanishi & 1 others Tetsushi Yoshikawa

Research output: Contribution to journalReview article

124 Citations (Scopus)

Abstract

Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

Original languageEnglish
Pages (from-to)863-870
Number of pages8
JournalArchives of Virology
Volume159
Issue number5
DOIs
Publication statusPublished - 01-01-2014

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Human Herpesvirus 6
Viruses

All Science Journal Classification (ASJC) codes

  • Virology

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Ablashi, D., Agut, H., Alvarez-Lafuente, R., Clark, D. A., Dewhurst, S., DiLuca, D., ... Yoshikawa, T. (2014). Classification of HHV-6A and HHV-6B as distinct viruses. Archives of Virology, 159(5), 863-870. https://doi.org/10.1007/s00705-013-1902-5
Ablashi, Dharam ; Agut, Henri ; Alvarez-Lafuente, Roberto ; Clark, Duncan A. ; Dewhurst, Stephen ; DiLuca, Dario ; Flamand, Louis ; Frenkel, Niza ; Gallo, Robert ; Gompels, Ursula A. ; Höllsberg, Per ; Jacobson, Steven ; Luppi, Mario ; Lusso, Paolo ; Malnati, Mauro ; Medveczky, Peter ; Mori, Yasuko ; Pellett, Philip E. ; Pritchett, Joshua C. ; Yamanishi, Koichi ; Yoshikawa, Tetsushi. / Classification of HHV-6A and HHV-6B as distinct viruses. In: Archives of Virology. 2014 ; Vol. 159, No. 5. pp. 863-870.
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Ablashi, D, Agut, H, Alvarez-Lafuente, R, Clark, DA, Dewhurst, S, DiLuca, D, Flamand, L, Frenkel, N, Gallo, R, Gompels, UA, Höllsberg, P, Jacobson, S, Luppi, M, Lusso, P, Malnati, M, Medveczky, P, Mori, Y, Pellett, PE, Pritchett, JC, Yamanishi, K & Yoshikawa, T 2014, 'Classification of HHV-6A and HHV-6B as distinct viruses', Archives of Virology, vol. 159, no. 5, pp. 863-870. https://doi.org/10.1007/s00705-013-1902-5

Classification of HHV-6A and HHV-6B as distinct viruses. / Ablashi, Dharam; Agut, Henri; Alvarez-Lafuente, Roberto; Clark, Duncan A.; Dewhurst, Stephen; DiLuca, Dario; Flamand, Louis; Frenkel, Niza; Gallo, Robert; Gompels, Ursula A.; Höllsberg, Per; Jacobson, Steven; Luppi, Mario; Lusso, Paolo; Malnati, Mauro; Medveczky, Peter; Mori, Yasuko; Pellett, Philip E.; Pritchett, Joshua C.; Yamanishi, Koichi; Yoshikawa, Tetsushi.

In: Archives of Virology, Vol. 159, No. 5, 01.01.2014, p. 863-870.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Classification of HHV-6A and HHV-6B as distinct viruses

AU - Ablashi, Dharam

AU - Agut, Henri

AU - Alvarez-Lafuente, Roberto

AU - Clark, Duncan A.

AU - Dewhurst, Stephen

AU - DiLuca, Dario

AU - Flamand, Louis

AU - Frenkel, Niza

AU - Gallo, Robert

AU - Gompels, Ursula A.

AU - Höllsberg, Per

AU - Jacobson, Steven

AU - Luppi, Mario

AU - Lusso, Paolo

AU - Malnati, Mauro

AU - Medveczky, Peter

AU - Mori, Yasuko

AU - Pellett, Philip E.

AU - Pritchett, Joshua C.

AU - Yamanishi, Koichi

AU - Yoshikawa, Tetsushi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

AB - Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

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JO - Archives of Virology

JF - Archives of Virology

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Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D et al. Classification of HHV-6A and HHV-6B as distinct viruses. Archives of Virology. 2014 Jan 1;159(5):863-870. https://doi.org/10.1007/s00705-013-1902-5