Classification of HHV-6A and HHV-6B as distinct viruses

Dharam Ablashi; Henri Agut; Roberto Alvarez-Lafuente; Duncan A. Clark; Stephen Dewhurst; Dario DiLuca; Louis Flamand; Niza Frenkel; Robert Gallo; Ursula A. Gompels; Per Höllsberg; Steven Jacobson; Mario Luppi; Paolo Lusso; Mauro Malnati; Peter Medveczky; Yasuko Mori; Philip E. Pellett; Joshua C. Pritchett; Koichi Yamanishi; Tetsushi Yoshikawa

doi:10.1007/s00705-013-1902-5

Classification of HHV-6A and HHV-6B as distinct viruses

Dharam Ablashi, Henri Agut, Roberto Alvarez-Lafuente, Duncan A. Clark, Stephen Dewhurst, Dario DiLuca, Louis Flamand, Niza Frenkel, Robert Gallo, Ursula A. Gompels, Per Höllsberg, Steven Jacobson, Mario Luppi, Paolo Lusso, Mauro Malnati, Peter Medveczky, Yasuko Mori, Philip E. Pellett, Joshua C. Pritchett, Koichi YamanishiTetsushi Yoshikawa

Pediatrics

Research output: Contribution to journal › Review article › peer-review

263 Citations (Scopus)

Abstract

Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.

Original language	English
Pages (from-to)	863-870
Number of pages	8
Journal	Archives of Virology
Volume	159
Issue number	5
DOIs	https://doi.org/10.1007/s00705-013-1902-5
Publication status	Published - 05-2014

All Science Journal Classification (ASJC) codes

Virology

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10.1007/s00705-013-1902-5

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Ablashi, D., Agut, H., Alvarez-Lafuente, R., Clark, D. A., Dewhurst, S., DiLuca, D., Flamand, L., Frenkel, N., Gallo, R., Gompels, U. A., Höllsberg, P., Jacobson, S., Luppi, M., Lusso, P., Malnati, M., Medveczky, P., Mori, Y., Pellett, P. E., Pritchett, J. C., ... Yoshikawa, T. (2014). Classification of HHV-6A and HHV-6B as distinct viruses. Archives of Virology, 159(5), 863-870. https://doi.org/10.1007/s00705-013-1902-5

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title = "Classification of HHV-6A and HHV-6B as distinct viruses",

abstract = "Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.",

author = "Dharam Ablashi and Henri Agut and Roberto Alvarez-Lafuente and Clark, {Duncan A.} and Stephen Dewhurst and Dario DiLuca and Louis Flamand and Niza Frenkel and Robert Gallo and Gompels, {Ursula A.} and Per H{\"o}llsberg and Steven Jacobson and Mario Luppi and Paolo Lusso and Mauro Malnati and Peter Medveczky and Yasuko Mori and Pellett, {Philip E.} and Pritchett, {Joshua C.} and Koichi Yamanishi and Tetsushi Yoshikawa",

year = "2014",

month = may,

doi = "10.1007/s00705-013-1902-5",

language = "English",

volume = "159",

pages = "863--870",

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Ablashi, D, Agut, H, Alvarez-Lafuente, R, Clark, DA, Dewhurst, S, DiLuca, D, Flamand, L, Frenkel, N, Gallo, R, Gompels, UA, Höllsberg, P, Jacobson, S, Luppi, M, Lusso, P, Malnati, M, Medveczky, P, Mori, Y, Pellett, PE, Pritchett, JC, Yamanishi, K & Yoshikawa, T 2014, 'Classification of HHV-6A and HHV-6B as distinct viruses', Archives of Virology, vol. 159, no. 5, pp. 863-870. https://doi.org/10.1007/s00705-013-1902-5

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AU - Ablashi, Dharam

AU - Agut, Henri

AU - Alvarez-Lafuente, Roberto

AU - Clark, Duncan A.

AU - Dewhurst, Stephen

AU - DiLuca, Dario

AU - Flamand, Louis

AU - Frenkel, Niza

AU - Gallo, Robert

AU - Gompels, Ursula A.

AU - Höllsberg, Per

AU - Jacobson, Steven

AU - Luppi, Mario

AU - Lusso, Paolo

AU - Malnati, Mauro

AU - Medveczky, Peter

AU - Mori, Yasuko

AU - Pellett, Philip E.

AU - Pritchett, Joshua C.

AU - Yamanishi, Koichi

AU - Yoshikawa, Tetsushi

PY - 2014/5

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Classification of HHV-6A and HHV-6B as distinct viruses

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