TY - JOUR
T1 - Classification of liver lesions based on temporal changes in hepatobiliary phase contrast on magnetic resonance imaging
T2 - a preliminary study
AU - Takatsu, Yasuo
AU - Nakamura, Masafumi
AU - Tateyama, Tomoko
AU - Miyati, Tosiaki
AU - Kobayashi, Satoshi
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics 2025.
PY - 2025
Y1 - 2025
N2 - This study evaluated whether temporal changes from the dynamic late phase to the hepatobiliary phase using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid supported liver tumor classification. A total of 147 patients with 165 lesions (hepatocellular carcinoma [HCC], metastases, and hemangiomas) underwent 3.0 T MRI. Quantitative liver lesion contrast (Q-LLC) and its rate of change (%) at 3, 10, and 15 min postcontrast were analyzed. Tumors were stratified according to albumin–bilirubin (ALBI) grade. For ALBI grade 1, the Q-LLC significantly differed at 3 min and 10 min (P < 0.05). Q-LLC increased over time, and the rate of change was the lowest in HCC, followed by metastases, and was the highest in hemangiomas. Significant differences in the rate of change were observed among tumor types for ALBI grade 1 (P < 0.01). These findings suggest that the Q-LLC rate of change may aid in liver tumor classification, particularly in patients with preserved liver function.
AB - This study evaluated whether temporal changes from the dynamic late phase to the hepatobiliary phase using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid supported liver tumor classification. A total of 147 patients with 165 lesions (hepatocellular carcinoma [HCC], metastases, and hemangiomas) underwent 3.0 T MRI. Quantitative liver lesion contrast (Q-LLC) and its rate of change (%) at 3, 10, and 15 min postcontrast were analyzed. Tumors were stratified according to albumin–bilirubin (ALBI) grade. For ALBI grade 1, the Q-LLC significantly differed at 3 min and 10 min (P < 0.05). Q-LLC increased over time, and the rate of change was the lowest in HCC, followed by metastases, and was the highest in hemangiomas. Significant differences in the rate of change were observed among tumor types for ALBI grade 1 (P < 0.01). These findings suggest that the Q-LLC rate of change may aid in liver tumor classification, particularly in patients with preserved liver function.
KW - Gd-EOB-DTPA
KW - Liver lesion classification
KW - Magnetic resonance imaging
KW - Quantitative liver lesion contrast
UR - https://www.scopus.com/pages/publications/105015568855
UR - https://www.scopus.com/inward/citedby.url?scp=105015568855&partnerID=8YFLogxK
U2 - 10.1007/s12194-025-00933-y
DO - 10.1007/s12194-025-00933-y
M3 - Article
C2 - 40911266
AN - SCOPUS:105015568855
SN - 1865-0333
JO - Radiological Physics and Technology
JF - Radiological Physics and Technology
ER -