Clear cell meningiomas: Three case reports with genetic characterization and review of the literature

Shigeo Oba, Hikaru Sasaki, Tokuhiro Kimura, Eiji Ikeda, Takeshi Kawase

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Abstract

Background and importance: Intracranial clear cell meningioma is very rare. We present 3 cases of intracranial clear cell meningiomas genetically characterized by comparative genomic hybridization with a review of the literature. Clinical presentation: Patient 1 is a 38-year-old woman with a petroclival tumor. Patient 2 is a 60-year-old man with a tumor at the foramen magnum. Patient 3 is a 60-year-old man with a tumor at the posterior clinoid process. Gross total resection was performed in patients 1 and 2. Patient 1 has been free from recurrence for 10 years. Patient 2 had a tumor recurrence at 14 months after the operation. After partial resection, conventional radiotherapy was given, and there was no tumor regrowth at 2 years after radiotherapy. Subtotal resection was performed in patient 3, and no regrowth was detected for 3 months. Histologically, all tumors were composed of cells with clear cytoplasm reactive for periodic acid-Schiff and diagnosed as clear cell meningioma. The MIB-1 and p53 staining indexes were 1.8, 1.7, and 5.6 and 1.1, 1.0, and 5.5, respectively. Comparative genomic hybridization revealed no chromosomal number aberrations in patient 1, numerous losses and gains including loss of chromosome 1 in patient 2, and loss of only 22q in patient 3. Because staining indexes of MIB-1 and p53 were equivalent in 2 patient (patients 1 and 2) with a long follow-up period, the contrary clinical courses are likely associated with genetic characteristics. Conclusion: To the best of our knowledge, this is the first report that suggests association between tumor behavior and genetic characteristics in clear cell meningiomas.

Original languageEnglish
JournalNeurosurgery
Volume67
Issue number3
DOIs
Publication statusPublished - 01-09-2010
Externally publishedYes

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Meningioma
Neoplasms
Comparative Genomic Hybridization
Radiotherapy
Foramen Magnum
Staining and Labeling
Recurrence
Periodic Acid
Chromosomes, Human, Pair 1
Chromosome Aberrations
Cytoplasm

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Surgery

Cite this

Oba, Shigeo ; Sasaki, Hikaru ; Kimura, Tokuhiro ; Ikeda, Eiji ; Kawase, Takeshi. / Clear cell meningiomas : Three case reports with genetic characterization and review of the literature. In: Neurosurgery. 2010 ; Vol. 67, No. 3.
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abstract = "Background and importance: Intracranial clear cell meningioma is very rare. We present 3 cases of intracranial clear cell meningiomas genetically characterized by comparative genomic hybridization with a review of the literature. Clinical presentation: Patient 1 is a 38-year-old woman with a petroclival tumor. Patient 2 is a 60-year-old man with a tumor at the foramen magnum. Patient 3 is a 60-year-old man with a tumor at the posterior clinoid process. Gross total resection was performed in patients 1 and 2. Patient 1 has been free from recurrence for 10 years. Patient 2 had a tumor recurrence at 14 months after the operation. After partial resection, conventional radiotherapy was given, and there was no tumor regrowth at 2 years after radiotherapy. Subtotal resection was performed in patient 3, and no regrowth was detected for 3 months. Histologically, all tumors were composed of cells with clear cytoplasm reactive for periodic acid-Schiff and diagnosed as clear cell meningioma. The MIB-1 and p53 staining indexes were 1.8, 1.7, and 5.6 and 1.1, 1.0, and 5.5, respectively. Comparative genomic hybridization revealed no chromosomal number aberrations in patient 1, numerous losses and gains including loss of chromosome 1 in patient 2, and loss of only 22q in patient 3. Because staining indexes of MIB-1 and p53 were equivalent in 2 patient (patients 1 and 2) with a long follow-up period, the contrary clinical courses are likely associated with genetic characteristics. Conclusion: To the best of our knowledge, this is the first report that suggests association between tumor behavior and genetic characteristics in clear cell meningiomas.",
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Clear cell meningiomas : Three case reports with genetic characterization and review of the literature. / Oba, Shigeo; Sasaki, Hikaru; Kimura, Tokuhiro; Ikeda, Eiji; Kawase, Takeshi.

In: Neurosurgery, Vol. 67, No. 3, 01.09.2010.

Research output: Contribution to journalArticle

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