TY - JOUR
T1 - Clinical analysis of 27 patients with malignant pleural mesothelioma treated at our institution
AU - Kikuchi, Hajime
AU - Asahina, Hajime
AU - Sakakibara-Konishi, Jun
AU - Shinagawa, Naofumi
AU - Oizumi, Satoshi
AU - Hida, Yasuhiro
AU - Kaga, Kichizo
AU - Inoue, Tetsuya
AU - Katoh, Norio
AU - Nishimura, Masaharu
N1 - Publisher Copyright:
© 2015 The Japan Lung Cancer Society.
PY - 2015/2/20
Y1 - 2015/2/20
N2 - Objective. We reviewed the clinical outcomes of patients with malignant pleural mesothelioma (MPM) treated at our institution. Methods. We conducted a retrospective analysis of 27 patients with MPM treated at our institution in the period from April 2005 to April 2013. Results. The patient characteristics were as follows: male/female = 26/1; age = 35-76 years (median, 62); histology: epithelioid/biphasic/sarcomatoid = 23/2/2; location, right/left = 14/13; clinical stage (IMIG) IA/IB/II/III/IV = 3/5/4/9/6. The initial treatment was surgery/ chemotherapy/best supportive care in 15/11/1 cases, including 14 patients treated with extrapleural pneumonectomy (EPP) and one patient treated with tumor resection. After EPP, three patients received adjuvant chemotherapy, five received hemithoracic radiotherapy (H-RT) and two received both. The median survival time (MST) of all patients was 21.8 months overall, compared to 30.7 months in the patients who received EPP. The patients who received H-RT after EPP demonstrated a significantly longer MST than those who did not (37.3 months vs. 12.0 months; p = 0.04). Conclusions. The use of H-RT after EPP is associated with a better prognosis.
AB - Objective. We reviewed the clinical outcomes of patients with malignant pleural mesothelioma (MPM) treated at our institution. Methods. We conducted a retrospective analysis of 27 patients with MPM treated at our institution in the period from April 2005 to April 2013. Results. The patient characteristics were as follows: male/female = 26/1; age = 35-76 years (median, 62); histology: epithelioid/biphasic/sarcomatoid = 23/2/2; location, right/left = 14/13; clinical stage (IMIG) IA/IB/II/III/IV = 3/5/4/9/6. The initial treatment was surgery/ chemotherapy/best supportive care in 15/11/1 cases, including 14 patients treated with extrapleural pneumonectomy (EPP) and one patient treated with tumor resection. After EPP, three patients received adjuvant chemotherapy, five received hemithoracic radiotherapy (H-RT) and two received both. The median survival time (MST) of all patients was 21.8 months overall, compared to 30.7 months in the patients who received EPP. The patients who received H-RT after EPP demonstrated a significantly longer MST than those who did not (37.3 months vs. 12.0 months; p = 0.04). Conclusions. The use of H-RT after EPP is associated with a better prognosis.
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U2 - 10.2482/haigan.55.2
DO - 10.2482/haigan.55.2
M3 - Article
AN - SCOPUS:84927618423
SN - 0386-9628
VL - 55
SP - 2
EP - 8
JO - Japanese Journal of Lung Cancer
JF - Japanese Journal of Lung Cancer
IS - 1
ER -