Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation

Preliminary results of a Japanese series

Yoshinori Okada, Yuji Matsumura, Hiroshi Date, Toru Bando, Takahiro Oto, Tetsu Sado, Yasushi Hoshikawa, Masafumi Noda, Hisashi Oishi, Takashi Kondo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation. Methods: The subjects were ten patients who received lung grafts preserved with EP-TU solution at three of four designated lung transplant centers between 2000 and 2005. Three of the patients underwent single lung transplantation and seven underwent bilateral lung transplantation. Postoperative graft function was evaluated by primary graft dysfunction (PGD) grade (0-3), arterial oxygen tension/inspired oxygen fraction (PaO 2/FiO 2) ratio, and the previously reported chest roentgenogram score (CRS, 0-4) during the first 48 h after intensive care unit admission. Survival rates were also calculated. Results: The average graft ischemic times for the first and second grafts were 431 and 571 min, respectively. The average PGD grade ranged from 0.5 to 1.0 and the average PaO 2/FiO 2 ratio ranged from 350 to 400 Torr during the 48 h. The average CRS was always under 1.0. Survival rates at 30 days and 5 years were 90 and 80%, respectively. Conclusions: EP-TU solution promoted excellent postoperative lung graft function and enhanced recipient survival rates, despite a long average preservation time.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalSurgery Today
Volume42
Issue number2
DOIs
Publication statusPublished - 01-01-2012
Externally publishedYes

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Phosphates
Transplants
Lung
Lung Transplantation
Primary Graft Dysfunction
Survival Rate
Oxygen
Intensive Care Units
Arterial Pressure
Thorax
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Okada, Yoshinori ; Matsumura, Yuji ; Date, Hiroshi ; Bando, Toru ; Oto, Takahiro ; Sado, Tetsu ; Hoshikawa, Yasushi ; Noda, Masafumi ; Oishi, Hisashi ; Kondo, Takashi. / Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation : Preliminary results of a Japanese series. In: Surgery Today. 2012 ; Vol. 42, No. 2. pp. 152-156.
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Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation : Preliminary results of a Japanese series. / Okada, Yoshinori; Matsumura, Yuji; Date, Hiroshi; Bando, Toru; Oto, Takahiro; Sado, Tetsu; Hoshikawa, Yasushi; Noda, Masafumi; Oishi, Hisashi; Kondo, Takashi.

In: Surgery Today, Vol. 42, No. 2, 01.01.2012, p. 152-156.

Research output: Contribution to journalArticle

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AU - Okada, Yoshinori

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AU - Date, Hiroshi

AU - Bando, Toru

AU - Oto, Takahiro

AU - Sado, Tetsu

AU - Hoshikawa, Yasushi

AU - Noda, Masafumi

AU - Oishi, Hisashi

AU - Kondo, Takashi

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N2 - Purpose: We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation. Methods: The subjects were ten patients who received lung grafts preserved with EP-TU solution at three of four designated lung transplant centers between 2000 and 2005. Three of the patients underwent single lung transplantation and seven underwent bilateral lung transplantation. Postoperative graft function was evaluated by primary graft dysfunction (PGD) grade (0-3), arterial oxygen tension/inspired oxygen fraction (PaO 2/FiO 2) ratio, and the previously reported chest roentgenogram score (CRS, 0-4) during the first 48 h after intensive care unit admission. Survival rates were also calculated. Results: The average graft ischemic times for the first and second grafts were 431 and 571 min, respectively. The average PGD grade ranged from 0.5 to 1.0 and the average PaO 2/FiO 2 ratio ranged from 350 to 400 Torr during the 48 h. The average CRS was always under 1.0. Survival rates at 30 days and 5 years were 90 and 80%, respectively. Conclusions: EP-TU solution promoted excellent postoperative lung graft function and enhanced recipient survival rates, despite a long average preservation time.

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