Clinical application of living-related conjunctival-limbal allograft

Kazuo Tsubota; Shigeto Shimmura; Naoshi Shinozaki; Edward J. Holland; Jun Shimazaki

doi:10.1016/S0002-9394(01)01208-9

Clinical application of living-related conjunctival-limbal allograft

Kazuo Tsubota, Shigeto Shimmura, Naoshi Shinozaki, Edward J. Holland, Jun Shimazaki

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.

Original language	English
Pages (from-to)	134-135
Number of pages	2
Journal	American journal of ophthalmology
Volume	133
Issue number	1
DOIs	https://doi.org/10.1016/S0002-9394(01)01208-9
Publication status	Published - 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Ophthalmology

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10.1016/S0002-9394(01)01208-9

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title = "Clinical application of living-related conjunctival-limbal allograft",

abstract = "PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.",

author = "Kazuo Tsubota and Shigeto Shimmura and Naoshi Shinozaki and Holland, {Edward J.} and Jun Shimazaki",

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AU - Tsubota, Kazuo

AU - Shimmura, Shigeto

AU - Shinozaki, Naoshi

AU - Holland, Edward J.

AU - Shimazaki, Jun

PY - 2002

Y1 - 2002

N2 - PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.

AB - PURPOSE: To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder. METHODS: Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered. RESULTS: Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction. CONCLUSION: A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.

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Clinical application of living-related conjunctival-limbal allograft

Abstract

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