Clinical burden of modified glasgow prognostic scale in colorectal cancer

Yoshinaga Okugawa; Yumiko Shirai; Yuji Toiyama; Susumu Saigusa; Asahi Hishida; Takeshi Yokoe; Koji Tanaka; Motoyoshi Tanaka; Hiromi Yasuda; Hiroyuki Fujikawa; Junichiro Hiro; Minako Kobayashi; Toshimitsu Araki; Yasuhiro Inoue; Donald C. McMillan; Masato Kusunoki; Chikao Miki

doi:10.21873/anticanres.12390

Clinical burden of modified glasgow prognostic scale in colorectal cancer

Yoshinaga Okugawa, Yumiko Shirai, Yuji Toiyama, Susumu Saigusa, Asahi Hishida, Takeshi Yokoe, Koji Tanaka, Motoyoshi Tanaka, Hiromi Yasuda, Hiroyuki Fujikawa, Junichiro Hiro, Minako Kobayashi, Toshimitsu Araki, Yasuhiro Inoue, Donald C. McMillan, Masato Kusunoki, Chikao Miki

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background/Aim: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and Methods: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

Original language	English
Pages (from-to)	1599-1610
Number of pages	12
Journal	Anticancer research
Volume	38
Issue number	3
DOIs	https://doi.org/10.21873/anticanres.12390
Publication status	Published - 03-2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/anticanres.12390

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Okugawa, Y., Shirai, Y., Toiyama, Y., Saigusa, S., Hishida, A., Yokoe, T., Tanaka, K., Tanaka, M., Yasuda, H., Fujikawa, H., Hiro, J., Kobayashi, M., Araki, T., Inoue, Y., McMillan, D. C., Kusunoki, M., & Miki, C. (2018). Clinical burden of modified glasgow prognostic scale in colorectal cancer. Anticancer research, 38(3), 1599-1610. https://doi.org/10.21873/anticanres.12390

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title = "Clinical burden of modified glasgow prognostic scale in colorectal cancer",

abstract = "Background/Aim: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and Methods: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.",

author = "Yoshinaga Okugawa and Yumiko Shirai and Yuji Toiyama and Susumu Saigusa and Asahi Hishida and Takeshi Yokoe and Koji Tanaka and Motoyoshi Tanaka and Hiromi Yasuda and Hiroyuki Fujikawa and Junichiro Hiro and Minako Kobayashi and Toshimitsu Araki and Yasuhiro Inoue and McMillan, {Donald C.} and Masato Kusunoki and Chikao Miki",

year = "2018",

month = mar,

doi = "10.21873/anticanres.12390",

language = "English",

volume = "38",

pages = "1599--1610",

journal = "Anticancer research",

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publisher = "International Institute of Anticancer Research",

number = "3",

}

Okugawa, Y, Shirai, Y, Toiyama, Y, Saigusa, S, Hishida, A, Yokoe, T, Tanaka, K, Tanaka, M, Yasuda, H, Fujikawa, H, Hiro, J, Kobayashi, M, Araki, T, Inoue, Y, McMillan, DC, Kusunoki, M & Miki, C 2018, 'Clinical burden of modified glasgow prognostic scale in colorectal cancer', Anticancer research, vol. 38, no. 3, pp. 1599-1610. https://doi.org/10.21873/anticanres.12390

TY - JOUR

T1 - Clinical burden of modified glasgow prognostic scale in colorectal cancer

AU - Okugawa, Yoshinaga

AU - Shirai, Yumiko

AU - Toiyama, Yuji

AU - Saigusa, Susumu

AU - Hishida, Asahi

AU - Yokoe, Takeshi

AU - Tanaka, Koji

AU - Tanaka, Motoyoshi

AU - Yasuda, Hiromi

AU - Fujikawa, Hiroyuki

AU - Hiro, Junichiro

AU - Kobayashi, Minako

AU - Araki, Toshimitsu

AU - Inoue, Yasuhiro

AU - McMillan, Donald C.

AU - Kusunoki, Masato

AU - Miki, Chikao

PY - 2018/3

Y1 - 2018/3

N2 - Background/Aim: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and Methods: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

AB - Background/Aim: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and Methods: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

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ER -

Clinical burden of modified glasgow prognostic scale in colorectal cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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