Clinical characteristics and long-term outcomes of hypertrophic cardiomyopathy: Results from the aichi hypertrophic cardiomyopathy (AHC) registry

Masataka Yoshinaga, Daiji Yoshikawa, Hideki Ishii, Akihiro Hirashiki, Takahiro Okumura, Aki Kubota, Shinichi Sakai, Ken Harada, Fuji Somura, Tomofumi Mizuno, Wakaya Fujiwara, Hiroatsu Yokoi, Mutsuharu Hayashi, Junichi Ishii, Yukio Ozaki, Toyoaki Murohara, Yukihiko Yoshida, Tetsuya Amano, Hideo Izawa

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Abstract

Hypertrophic cardiomyopathy (HCM) has various morphological and clinical features. A decade has passed since the previous survey of the epidemiological and clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational study of HCM patients. The clinical characteristics of 42 ambulant HCM patients followed up for up to 5 years were investigated. The primary endpoint was major adverse cardiac events (MACE), defined as death, non-fatal stroke, admission due to congestive heart failure (CHF), or episodes of sustained ventricular tachycardia/fibrillation. The MACE-free survival during the 5-year follow-up period was 76% according to Kaplan–Meier analysis. HCM-related death occurred in 3 (7%) patients and SCD occurred in 2 (5%) patients. Additionally, 3 (7%) patients were admitted to the hospital due to CHF. Meanwhile, sustained VT was detected in one (2%) of the patients who received ICD implantation and subsequently terminated with antitachycardia pacing using an ICD. The patients with HCM exhibiting left ventricular outflow obstruction (HOCM) had a slightly lower MACE-free survival rate than those with neither HOCM nor dilated-HCM (dHCM) (71% versus 81%, log-rank P = 0.581). Furthermore, the patients with dHCM demonstrated a significantly lower MACE-free survival rate than those with neither HOCM nor dHCM (33% versus 81%, log-rank P = 0.029). In the AHC Registry targeting current Japanese HCM patients, we demonstrated that many HCM patients continue to suffer from MACE despite the development of various treatments for HCM.

Original languageEnglish
Pages (from-to)415-420
Number of pages6
JournalInternational heart journal
Volume56
Issue number4
DOIs
Publication statusPublished - 13-07-2015

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Yoshinaga, M., Yoshikawa, D., Ishii, H., Hirashiki, A., Okumura, T., Kubota, A., Sakai, S., Harada, K., Somura, F., Mizuno, T., Fujiwara, W., Yokoi, H., Hayashi, M., Ishii, J., Ozaki, Y., Murohara, T., Yoshida, Y., Amano, T., & Izawa, H. (2015). Clinical characteristics and long-term outcomes of hypertrophic cardiomyopathy: Results from the aichi hypertrophic cardiomyopathy (AHC) registry. International heart journal, 56(4), 415-420. https://doi.org/10.1536/ihj.14-418