TY - JOUR
T1 - Clinical characteristics and long-term prognosis of autoimmune pancreatitis with renal lesions
AU - Ishikawa, Takuya
AU - Kawashima, Hiroki
AU - Ohno, Eizaburo
AU - Iida, Tadashi
AU - Suzuki, Hirotaka
AU - Uetsuki, Kota
AU - Yashika, Jun
AU - Yamada, Kenta
AU - Yoshikawa, Masakatsu
AU - Gibo, Noriaki
AU - Aoki, Toshinori
AU - Kataoka, Kunio
AU - Mori, Hiroshi
AU - Yamamura, Takeshi
AU - Furukawa, Kazuhiro
AU - Nakamura, Masanao
AU - Hirooka, Yoshiki
AU - Fujishiro, Mitsuhiro
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Autoimmune pancreatitis (AIP) is recognized as the pancreatic manifestation of a systemic IgG4-related disease that can involve various organs, including the kidney. However, renal lesions tend to be overlooked when AIP is diagnosed, and the clinical characteristics and long-term prognosis of AIP with renal lesions are unclear. We retrospectively reviewed 153 patients with AIP diagnosed at our hospital with a median follow-up period of 41 months (interquartile range, 10–86) and classified them into two groups: the KD group (n = 17), with characteristic renal imaging features, and the non-KD group (n = 136). Serum IgG4 levels were significantly higher in the KD group (663 vs. 304.5 mg/dl, P = 0.014). No differences were observed between the two groups in terms of steroid treatment [14/17 (82.4%) vs. 112/136 (82.4%), P = 1] or in the number of patients who exhibited exacerbation of renal function during treatment [1/17 (5.9%) vs. 8/136 (5.9%), P = 1]. However, the cumulative relapse rate was significantly higher in the KD group [61% vs. 21.9% (3 years), P < 0.001]. Patients in the KD group had different clinical features with high relapse rates compared with those in the non-KD group, and thus, it is important to confirm the presence of renal lesions in AIP patients.
AB - Autoimmune pancreatitis (AIP) is recognized as the pancreatic manifestation of a systemic IgG4-related disease that can involve various organs, including the kidney. However, renal lesions tend to be overlooked when AIP is diagnosed, and the clinical characteristics and long-term prognosis of AIP with renal lesions are unclear. We retrospectively reviewed 153 patients with AIP diagnosed at our hospital with a median follow-up period of 41 months (interquartile range, 10–86) and classified them into two groups: the KD group (n = 17), with characteristic renal imaging features, and the non-KD group (n = 136). Serum IgG4 levels were significantly higher in the KD group (663 vs. 304.5 mg/dl, P = 0.014). No differences were observed between the two groups in terms of steroid treatment [14/17 (82.4%) vs. 112/136 (82.4%), P = 1] or in the number of patients who exhibited exacerbation of renal function during treatment [1/17 (5.9%) vs. 8/136 (5.9%), P = 1]. However, the cumulative relapse rate was significantly higher in the KD group [61% vs. 21.9% (3 years), P < 0.001]. Patients in the KD group had different clinical features with high relapse rates compared with those in the non-KD group, and thus, it is important to confirm the presence of renal lesions in AIP patients.
UR - https://www.scopus.com/pages/publications/85099249388
UR - https://www.scopus.com/pages/publications/85099249388#tab=citedBy
U2 - 10.1038/s41598-020-79899-3
DO - 10.1038/s41598-020-79899-3
M3 - Article
C2 - 33432048
AN - SCOPUS:85099249388
SN - 2045-2322
VL - 11
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 406
ER -